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1. Introduction
2. The blood-brain barrier
3. The neurovascular unit
4. Physiological functions within the NVU
5. Pathways across the BBB
6. The glucose uniporter family
7. GLUTs in the brain
8. Glucose transporters in the BBB
9. GLUT-1 deficiency syndrome
10. Brain energy substrates
11. Glucose hurdles in the NVU (1)
12. Lower GLUT-1 densities in astrocytes than in BBB
13. Glucose hurdles in the NVU (2)
14. Properties of BBB glucose transport
15. Baseline glucose utilization and transport
16. Transporter densities and glucose utilization
17. A simple and widely used transport model
18. Glucose concentrations
19. Kinetic transport parameters
20. GLUT-1 topology and kinetic constants
21. BBB glucose transport - baseline setpoint
22. Glucose transport in baseline and during activation
23. Neurovascular coupling (NVC)
24. Feeding our thoughts
25. Neurometabolic coupling (NMC) (1)
26. Astrocyte-neuron lactate shuttle
27. Neurometabolic coupling (NMC) (2)
28. Coupling in the NVU
29. Neurobarrier coupling (NBC)
30. Possibilities to stimulate BBB glucose transport
31. Analysis of the LMA effect (1)
32. Glucose dynamics following brain activation
33. Analysis of the LMA effect (2)
34. Glycogen in brain astrocytes
35. Glucose transport at the next hurdle
36. In vitro evidence for G transport modulation
37. In vivo evidence for GLUT-1 stimulation
38. Mechanisms for GLUT-1 stimulation
39. Considerations on G transport
40. Two roadmaps for G to arrive at the neurons
41. BBB GLUT-1 transporters
42. Conclusion

Topics Covered

• Functions of the neurovascular unit
• Brain energy substrates
• Pathways across the blood-brain barrier
• Glucose utilization and transport
• Glucose uniporters
• Kinetic transport parameters
• Glucose transport in baseline and during activation
• Neurovascular coupling
• Neurometabolic coupling
• Neurobarrier coupling
• Dynamic changes of glucose concentration
• GLUT-1 stimulation in vitro and in vivo
• Roadmaps for glucose from blood to neurons

Links

Series:

• The Blood-Brain Barrier

Categories:

• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 1, 2008
• Archived on October 28, 2018

Financial Disclosures

• Prof. Luc Leybaert has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.