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- Structure of the blood-brain barrier
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36 min
1. The blood-brain barrier in Alzheimer’s disease- Dr. Anika Hartz
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35 min
2. Tanycytes allow a tight BBB in the median eminence- Prof. Esteban Rodriguez
- Dr. Juan Luis Blazquez
- Dr. Montserrat Guerra
- Nutrient transport
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35 min
3. Blood-brain barrier ion transport- Prof. Martha O'Donnell
- Peptides and proteins
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37 min
4. Ingestive peptides- Prof. William Banks
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62 min
5. Blood-brain barrier in health and disease- Prof. Thomas Davis
- Overcoming the blood-brain barrier obstacle
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42 min
6. Expression vs. function of ABC transporters at the blood-brain barrier- Prof. Jean-Michel Scherrmann
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44 min
7. The blood-brain barrier and CNS drug development- Dr. Danica Stanimirovic
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34 min
- Diseases involving the blood-brain barrier
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71 min
9. Inflammation and immune cell entry to the central nervous system- Prof. Serge Rivest
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42 min
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24 min
11. Ischemic blood-brain barrier and Alzheimer's amyloid plaques development- Prof. Ryszard Pluta
- Latest Developments in the Field
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31 min
12. MRI approaches for neurovascular imaging- Dr. Rick Dijkhuizen
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33 min
13. Brain-gut interactions in obesity 1- Prof. Weihong Pan
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19 min
14. Brain-gut interactions in obesity 2- Prof. Weihong Pan
- Archived Lectures *These may not cover the latest advances in the field
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36 min
15. Neurotrophins and the BBB- Prof. Weihong Pan
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52 min
16. Vasoactive peptides and the blood-brain barrier- Prof. Maria Deli
- Prof. Bela Kis
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42 min
17. In vivo systems- Prof. Quentin Smith
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46 min
18. CNS-drug design- Prof. Quentin Smith
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43 min
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23 min
20. Stroke and the BBB- Prof. Marilyn Cipolla
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54 min
21. Barrier mechanisms in the developing brain: mechanisms and misunderstandings- Prof. Norman Saunders
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57 min
22. Barrier mechanisms in the developing brain: protection or vulnerability?- Prof. Norman Saunders
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43 min
23. In vitro models of the blood-brain barrier- Prof. Pierre-Olivier Couraud
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41 min
24. Glucose transport across the blood-brain barrier- Prof. Luc Leybaert
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53 min
25. The blood-brain barrier and brain tumors- Dr. Olaf van Tellingen
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37 min
26. Cellular composition of the blood-brain barrier- Prof. N. Joan Abbott
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48 min
27. Features of mammalian CNS barrier systems- Prof. Conrad Johanson
Printable Handouts
Navigable Slide Index
- Introduction
- Outline of presentation
- Central nervous system diseases
- Drug market for CNS disorders
- Traditional CNS drug targets
- Novel CNS drug targets
- Multiple obstacles for drug delivery to CNS
- Pathways for drug exchange within the CNS
- Factors affecting brain drug delivery and exchange
- The structure of brain capillaries impedes uptake
- Measures of drug uptake and distribution in brain
- BBB permeability and solute lipid solubility
- Tissues capillary PS and 95% equilibration time
- Cerebral blood flow affects drug uptake and Kin
- Initial uptake vs. steady-state distribution
- Plasma protein binding and brain drug uptake
- Example of the impact of plasma protein binding
- Brain capillary drug transporters
- Transporters and drug distribution across BBB
- "Enzymatic" blood-brain barrier
- Drug distribution in brain at steady state
- Relation between bound and free drug
- Free drug distribution ratio at steady state
- BBB changes in pathology and disease
- Drug-like properties to cross the BBB
- Early findings in BBB drug uptake
- Measures of lipophilicity
- Passive permeability across lipid membranes
- Drug ionization
- Influence of pH on neutral fraction
- Lipinski "rule of five"
- "Rule of five" modified for CNS drugs
- Impact of hydrogen bonds and alkyl groups
- Examples of positive CNS drugs
- Example of a poor CNS drug
- Other in vitro measures
- In vivo measures
- Methods to improve brain uptake
- Simple rules for efflux transporters
- % drug distribution to brain
- Biologic compounds
- Closing comments of brain pharmacokinetics
- Summary
- Acknowledgements
Topics Covered
- Central nervous system diseases
- Drug market for CNS disorders
- Traditional CNS drug targets
- Novel CNS drug targets
- Multiple obstacles for drug delivery to CNS
- Pathways for drug exchange within the CNS
- The structure of brain capillaries impedes uptake
- Measures of drug uptake and distribution in brain
- BBB permeability and solute lipid solubility
- Tissues capillary PS and 95% equilibration time
- Cerebral blood flow affects drug uptake and Kin
- Initial uptake vs. steady-state distribution
- Plasma protein binding and brain drug uptake
- Brain capillary drug transporters
- Transporters and drug distribution across BBB
- "Enzymatic" blood-brain barrier
- Relation between bound and free drug
- Free drug distribution ratio at steady state
- BBB changes in pathology and disease
- Drug-like properties to cross the BBB
- Early findings in BBB drug uptake
- Measures of lipophilicity
- Passive permeability across lipid membranes
- Drug ionization
- Influence of pH on neutral fraction
- Lipinski "rule of five"
- Impact of hydrogen bonds and alkyl groups
- Positive CNS drugs
- Poor CNS drug
- in vitro measures
- In vivo measures
- Methods to improve brain uptake
- Simple rules for efflux transporters
- % drug distribution to brain
- Biologic compounds
- Brain pharmacokinetics
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Smith, Q. (2008, March 1). CNS-drug design [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/EJEM3763.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Quentin Smith has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
