• Statistical Genetics of Complex Diseases
• 38 min
  1. Population genetics considerations

  • Prof. Nan Laird
• 39 min
  2. Gene-by-environment interaction: study designs and analytical methods

  • Prof. L. Adrienne Cupples
• 59 min
  3. Analysis of SNP haplotypes

  • Prof. Lyle Palmer
• 36 min
  4. Statistical issues in epidemiological studies of gene-environment interaction

  • Dr. Peter Kraft
  • Prof. Donna Spiegelman
• Molecular Epidemiology of Pulmonary Diseases
• 57 min
  5. Molecular epidemiology of lung cancer

  • Prof. David Christiani
• 34 min
  6. Ethical issues in molecular epidemiology and studies of gene-environment interactions

  • Dr. Richard Sharp
• Autoimmune Diffuse Connective Tissue Diseases
• 29 min
  7. Environmental scleroderma: the evidence for putative triggers

  • Prof. Maureen Mayes
• Drug-Induced Disease
• 35 min
  8. Drug-induced lupus

  • Prof. Evelyn Hess
• Archived Lectures *These may not cover the latest advances in the field
• 41 min
  9. Biomarkers of exposure

  • Prof. Thomas Smith
• 43 min
  10. GIS and spatial statistics

  • Prof. Louise Ryan
• 47 min
  11. Gene-by-environment interactions in COPD

  • Prof. Edwin Silverman
• 40 min
  12. Occupational and environmental influences on the development and course of lupus

  • Dr. Glinda Cooper
• 54 min
  13. Genetic susceptibility in granulomatous disorders: chronic beryllium disease and sarcoidosis

  • Prof. Lee Newman
• 29 min
  14. Indians, twins and scleroderma: genetic and genomic studies

  • Prof. Frank Arnett
• 27 min
  15. Gene by environment interaction in asthma

  • Prof. Scott Weiss
• 42 min
  16. Molecular epidemiology of lung cancer

  • Prof. David Christiani
• 18 min
  17. Racial and ethnic variation in systemic lupus erythematosus and systemic sclerosis (scleroderma)

  • Dr. Patricia Fraser
• 47 min
  18. Infectious environmental factors and systemic lupus erythematosus

  • Prof. Judith James

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline
3. Gene by environment interaction - definitions
4. Gene by environment interaction - examples
5. Study designs and types of measures
6. Study designs
7. Dichotomous traits - classical case-control study
8. Case-control study - odds ratio
9. Case-only study
10. Example - case-control and case-only studies
11. Additive vs. multiplicative scales
12. Case-only vs. case-control studies
13. Discordant affected twin studies
14. Discordant affected twin studies - odds ratio
15. Study designs: issues
16. Study designs: family studies
17. G x e interactions vs. genetic heterogeneity
18. Genetic heterogeneity - examples
19. Genetic heterogeneity
20. Linkage analyses strategies
21. Ordered subsets - goal and strategy
22. Desighning ordered subsets
23. Ordered subset - evaluating significance
24. Ordered subset - example
25. Ordered subset - graph for example
26. G x e stratified analysis - goal
27. G x e stratified analysis - example
28. G x e stratified analysis - graph for example
29. Variance component g x e modeling
30. Extension of the model
31. Tests for interactions
32. G x e modeling - example
33. Polygenic model
34. Results of the modeling
35. Model's conclusions
36. Pedigree-based association analysis
37. Pedigree-based association analysis - variables
38. PBAT - test based on score statistics
39. PBAT - example
40. PBAT - results of example
41. Summary

Topics Covered

• Study designs that evaluate the joint effects of gene-by-environment interactions, including case-control, case only, matched pairs, random samples and family studies
• Distinguishing between gene-by-environment interaction and genetic heterogeneity
• Description of analytical procedures and effect measures for evaluation of gene-by-environment interaction for dichotomous and continuous outcomes
• Case-control, case only, ordered subset, variance component and PBAT analyses

Links

Series:

• Gene-Environment Interactions

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. L. Adrienne Cupples has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.