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1. Introduction
2. Major transport interfaces in CNS
3. Features of mammalian CNS barrier systems
4. Topical presentation overview (1)
5. The choroid plexus system
6. Choroid plexus spurs brain development
7. Ramifying choroidal fronds and villi
8. Ultrastructure of choroidal epithelium
9. Schematic reconstruction of villus from EMs
10. Topical presentation overview (2)
11. Choroid plexus hemodynamics/hydrodynamics
12. CSF formation by choroid plexus
13. Transport mechanisms in choroidal epithelium
14. Pharmacologic modulation of CSF formation
15. Neuroendocrine regulation of CSF formation
16. Topical presentation overview (3)
17. Distribution of choroidal secretions to brain
18. Distribution of solutes from blood to brain
19. CSF-borne growth factors
20. A unique CSF transport pathway
21. Disruptions in CSF homeostasis
22. Topical presentation overview (4)
23. Why study BCSFB permeability and its breakdown
24. Quantifying the permeability of the BCSF barrier
25. Hypertension disruption of BCSF barrier
26. Hyperthermia damage to BCSF barrier
27. Ischemia disruption of the BCSF barrier
28. Topical presentation overview (5)
29. Kidney-like functions of choroid plexus
30. CSF turnover rate changes with aging
31. Choroid plexus dwindling in late stages of life
32. Loss of CSF sink action
33. Translational research opportunities
34. Conclusions

Topics Covered

• Choroid plexus
• Formation of CSF
• Permeability of blood
• CSF barrier vs. blood-brain barrier
• Choroidal secretion of peptides, growth factors and regulatory proteins
• Homeostasis and bulk flow of extracellular fluid in the CNS
• Impact of CSF dynamics on brain metabolism
• Disrupted transport at the blood-CSF interface in hyperthermia, ischemia and Alzheimer's disease
• Reduced CSF reabsorption in aging, hydrocephalus and dementia

Links

Series:

• The Blood-Brain Barrier

Categories:

• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on March 1, 2008
• Archived on December 10, 2018

Financial Disclosures

• Prof. Conrad Johanson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.