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Printable Handouts
Navigable Slide Index
- Genetic variability in PON1
- PON1 in health and disease
- Goals of presentation
- Origin of paraoxonase name
- Serum PON1 activity
- PON1 polymorphisms
- Additional PON1 SNPs discovered
- Properties of human PON1
- P450-PON pathway for detoxification
- PON1 genetic variability - conseq.
- Determination of PON1 status
- PON1 function in rodent models
- Increased plasma levels of PON1
- High PON1 levels protection
- Low PON1 levels - consequences
- PON1 +/+, +/-, -/- activity levels
- Chlorpyrifos oxon - PON1 +/+, -/-
- Diazoxon - PON1 +/+, +/-, -/-
- Paraoxon - PON1 +/+, +/-, -/-
- In vivo efficacy of PON1 detox.
- Young individuals and OP sensitivity
- Dev. onset of PON1 activity in child.
- Mouse lines carrying human PON1
- hPON1 activity - in Q192/R192 mice
- Sensitivity to CPO toxicity
- Chlorpyrifos oxon exposure
- OP pesticide exposure - conseq.
- Role of PON1192 polymorphism
- Mixed exposures
- Chlorpyrifos oxon/malaoxon expos.
- PON1 mutants - PBPK/PD
- PBPK simulation of AChE activities
- Test of model in PON1 -/- mice
- Genetically variable PON1 status
- PON1 status availability
- Impacts of PON1 genetic variations
- PON1 in health and disease
- Physiological role of PON1
- PON1 activity levels
- PON1 in health and disease
- Important lactone substrates
- Enzymatic activities of hPONs
- Paraoxonases - drug inactiv./activ.
- PON1 in health and disease
- Hydrolysis of 3-O-HSL by PONs
- Avenues of expl. in PON1 KO mice
- OPs detoxication in PON1 KO mice
- The bottom line
- Summary
- PON1 collaborators
- References from the author (1)
- References from the author (2)
- References from the author (3)
Topics Covered
- Paraoxonase (PON1)
- Hydrolytic reactions
- Enzyme properties
- Polymorphisms
- Use of mouse models
- PON1 levels in human populations
- PON1 status as a risk factor in carotid artery disease
- Designing epidemiological studies for examining PON1 genetic variability and risk
Links
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Talk Citation
Furlong, C. (2007, October 1). Genetic variability in Paraoxonase 1 (PON1), an HDL associated esterase: impact on risk and pharmacokinetics [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 1, 2024, from https://doi.org/10.69645/BMYL4915.Export Citation (RIS)
Publication History
Financial Disclosures
- Res. Prof. Clement Furlong has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Genetic variability in Paraoxonase 1 (PON1), an HDL associated esterase: impact on risk and pharmacokinetics
A selection of talks on Pharmaceutical Sciences
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