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1. Genetic variability in PON1
2. PON1 in health and disease
3. Goals of presentation
4. Origin of paraoxonase name
5. Serum PON1 activity
6. PON1 polymorphisms
7. Additional PON1 SNPs discovered
8. Properties of human PON1
9. P450-PON pathway for detoxification
10. PON1 genetic variability - conseq.
11. Determination of PON1 status
12. PON1 function in rodent models
13. Increased plasma levels of PON1
14. High PON1 levels protection
15. Low PON1 levels - consequences
16. PON1 +/+, +/-, -/- activity levels
17. Chlorpyrifos oxon - PON1 +/+, -/-
18. Diazoxon - PON1 +/+, +/-, -/-
19. Paraoxon - PON1 +/+, +/-, -/-
20. In vivo efficacy of PON1 detox.
21. Young individuals and OP sensitivity
22. Dev. onset of PON1 activity in child.
23. Mouse lines carrying human PON1
24. hPON1 activity - in Q192/R192 mice
25. Sensitivity to CPO toxicity
26. Chlorpyrifos oxon exposure
27. OP pesticide exposure - conseq.
28. Role of PON1192 polymorphism
29. Mixed exposures
30. Chlorpyrifos oxon/malaoxon expos.
31. PON1 mutants - PBPK/PD
32. PBPK simulation of AChE activities
33. Test of model in PON1 -/- mice
34. Genetically variable PON1 status
35. PON1 status availability
36. Impacts of PON1 genetic variations
37. PON1 in health and disease
38. Physiological role of PON1
39. PON1 activity levels
40. PON1 in health and disease
41. Important lactone substrates
42. Enzymatic activities of hPONs
43. Paraoxonases - drug inactiv./activ.
44. PON1 in health and disease
45. Hydrolysis of 3-O-HSL by PONs
46. Avenues of expl. in PON1 KO mice
47. OPs detoxication in PON1 KO mice
48. The bottom line
49. Summary
50. PON1 collaborators
51. References from the author (1)
52. References from the author (2)
53. References from the author (3)

Topics Covered

• Paraoxonase (PON1)
• Hydrolytic reactions
• Enzyme properties
• Polymorphisms
• Use of mouse models
• PON1 levels in human populations
• PON1 status as a risk factor in carotid artery disease
• Designing epidemiological studies for examining PON1 genetic variability and risk

Links

Series:

• Drug Metabolizing Enzymes

Categories:

• Biochemistry
• Metabolism & Nutrition
• Pharmaceutical Sciences

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Furlong, C. (2007, October 1). Genetic variability in Paraoxonase 1 (PON1), an HDL associated esterase: impact on risk and pharmacokinetics [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/BMYL4915.
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Publication History

• Published on October 1, 2007
• Archived on December 10, 2018

Financial Disclosures

• Res. Prof. Clement Furlong has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.