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Printable Handouts
Navigable Slide Index
- Nuclear receptor (NR) superfamily
- Content of presentation
- Detoxication function
- Gene transcription
- Regulation of gene expression
- Signaling pathways
- NR-mediated gene activation
- NRs in drug metabolism induction
- Xenobiotic/drug metabolism
- AhR - general
- AhR signal transduction
- PXR - general
- PXR - signal transduction
- hPXR LBD x-ray structure
- CAR - general
- CAR - signal transduction
- hCAR/PXR LBD x-ray structure
- CAR/PXR - ligands/activators
- CAR/PXR - target genes
- CYP3A4 promoter organization
- Drug metabolism induction
- CAR/PXR - knockout animals
- Induction - species-specificity
- Induction - variability in man (1)
- Induction - variability in man (2)
- P450s and CAR/PXR redundancies
- Drug metab. induction - examples
- Preparation of human hepatocytes
- CYP mRNAs induction in hepatoc.
- CYP proteins induction in hepatoc.
- CYP activity induction in hepatoc.
- Conclusion
Topics Covered
- Drug metabolism and gene transcription
- Role of nuclear receptors in drug metabolism induction
- Aryl hydrocarbon receptor
- Pregnane X receptor
- Constitutive androstane receptor
- Human examples of drug metabolism induction
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Talk Citation
Maurel, P. (2007, October 1). General factors affecting drug metabolism: the role of nuclear receptor superfamily members in induction [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 23, 2024, from https://doi.org/10.69645/NTQO5552.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Patrick Maurel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
General factors affecting drug metabolism: the role of nuclear receptor superfamily members in induction
A selection of talks on Cardiovascular & Metabolic
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