Integral gene drives for malaria control
29 min
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38 min
1. Histone dynamics, heritability and variants- Dr. Genevieve Almouzni
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41 min
2. The RNA polymerase II general transcription machinery- Prof. Michael Hampsey
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42 min
3. Introduction to chromatin structure- Prof. Karolin Luger
- Archived Lectures *These may not cover the latest advances in the field
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46 min
4. Transcription elongation control by RNA polymerase II- Dr. Ali Shilatifard
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41 min
5. The mechanisms and control of mRNA turnover in eukaryotic cells- Prof. Roy Parker
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38 min
6. Coupling transcription, RNA processing and RNA export- Prof. Grant Hartzog
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56 min
7. Dynamic chromatin: ATP-dependent chromatin remodeling machines- Prof. Bradley Cairns
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51 min
8. DNA methylation- Prof. Steve Jacobsen
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48 min
9. Visualization of transcription factor interactions in living cells- Prof. Tom Kerppola
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44 min
10. Accessing and using ENCODE data- Prof. Peggy Farnham
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35 min
11. The beta-globin locus- Dr. Ann Dean
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65 min
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33 min
13. Transcriptional activation- Prof. Arnold Berk
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31 min
14. The regulation of Pre-Messenger RNA splicing- Prof. Douglas Black
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67 min
15. The E2F family and transcriptional control of the mammalian cell cycle- Prof. Brian Dynlacht
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36 min
16. Genome-wide analyses of protein-DNA interactions- Prof. Peggy Farnham
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48 min
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27 min
18. Gene silencing by Polycomb complexes- Prof. Yi Zhang
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41 min
19. Eukaryotic gene regulation: from chromatin to transcription to mRNA processing- Prof. Michael Carey
- Prof. Stephen Smale
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34 min
20. Epigenetic information in gene expression and cancer- Prof. Siavash Kurdistani
Printable Handouts
Navigable Slide Index
- Intro slide
- The central dogma of molecular biology
- Eukaryotes process their RNA
- Studies of the individual steps of gene expression
- Transcription, RNA export & processing are linked
- Coordination of events in gene expression pathway
- The capping process
- The splicing process
- The polyadenylation process
- Polyadenylation and termination are coupled
- The RNA polymerase II C-terminal domain (CTD)
- CTD phosphorylation during transcription
- CTD phosphorylation controls protein binding
- Advantages of using the CTD as a scaffold (1)
- Advantages of using the CTD as a scaffold (2)
- Advantages of using the CTD as a scaffold (3)
- Capping and the ordering of processing events
- Splicing depends upon recognition of sequences
- Splicing in multi-intron genes
- RNA processing occurs during transcription
- RNA is prepared for export during transcription
- RNA export
- Advantages of linking export to processing
- Summary
- Transcription and alternative splicing (1)
- Transcription and alternative splicing (2)
- Promoter effects on alternative splicing
- Enabling alternative splice site usage (1)
- Enabling alternative splice site usage (2)
- Polar effects in splicing
- Factors that regulate elongation (1)
- Factors that regulate elongation (2)
- Challenges to studying linkages between steps
- Genome-wide analysis of gene expression
- Analysis of gene expression (1)
- Analysis of gene expression (2)
- Clustering splicing microarray data
- Classify expression defects
- Conclusions
- Further reading
Topics Covered
- Mechanistic coupling of RNA processing, export and transcription
- Current evidence supporting coupling mechanisms
- Role of the RNA polymerase II CTD
- Competition during transcription between RNA binding proteins
- Future challenges and directions
Talk Citation
Hartzog, G. (2007, October 1). Coupling transcription, RNA processing and RNA export [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 31, 2025, from https://doi.org/10.69645/RYAB6026.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Grant Hartzog has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
