• View the Talks
• 38 min
  1. Histone dynamics, heritability and variants

  • Dr. Genevieve Almouzni
• 41 min
  2. The RNA polymerase II general transcription machinery

  • Prof. Michael Hampsey
• 42 min
  3. Introduction to chromatin structure

  • Prof. Karolin Luger
• Archived Lectures *These may not cover the latest advances in the field
• 46 min
  4. Transcription elongation control by RNA polymerase II

  • Dr. Ali Shilatifard
• 41 min
  5. The mechanisms and control of mRNA turnover in eukaryotic cells

  • Prof. Roy Parker
• 38 min
  6. Coupling transcription, RNA processing and RNA export

  • Prof. Grant Hartzog
• 56 min
  7. Dynamic chromatin: ATP-dependent chromatin remodeling machines

  • Prof. Bradley Cairns
• 51 min
  8. DNA methylation

  • Prof. Steve Jacobsen
• 48 min
  9. Visualization of transcription factor interactions in living cells

  • Prof. Tom Kerppola
• 44 min
  10. Accessing and using ENCODE data

  • Prof. Peggy Farnham
• 35 min
  11. The beta-globin locus

  • Dr. Ann Dean
• 65 min
  12. The transcription factor NF-Kappa B: an evolutionarily conserved mediator of immune and inflammatory responses

  • Prof. Sankar Ghosh
• 33 min
  13. Transcriptional activation

  • Prof. Arnold Berk
• 31 min
  14. The regulation of Pre-Messenger RNA splicing

  • Prof. Douglas Black
• 67 min
  15. The E2F family and transcriptional control of the mammalian cell cycle

  • Prof. Brian Dynlacht
• 36 min
  16. Genome-wide analyses of protein-DNA interactions

  • Prof. Peggy Farnham
• 48 min
  17. Histone modification and transcriptional repression

  • Dr. Yang Shi
• 27 min
  18. Gene silencing by Polycomb complexes

  • Prof. Yi Zhang
• 41 min
  19. Eukaryotic gene regulation: from chromatin to transcription to mRNA processing

  • Prof. Michael Carey
  • Prof. Stephen Smale
• 34 min
  20. Epigenetic information in gene expression and cancer

  • Prof. Siavash Kurdistani

Printable Handouts

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Navigable Slide Index

1. Intro slide
2. Regulation of gene expression by RNA pol ll
3. The basal transcription machinery
4. The initiation and elongation factors
5. The process of transcription cycle
6. The rate of transcription elongation
7. Different classes of RNA pol ll elongation factors
8. Factors increasing the rate of transcribing RNA pol
9. Factors assisting through transient pausing sites
10. Factors assisting to transcribe through chromatin
11. Factors without biochemical activities
12. Factors increasing transcription rate of RNA pol. II
13. ELL increase the catalytic rate of elongation
14. MLL and ELL chimera
15. Immortalization of primary progenitor cells
16. The results of immortalization experiment
17. ELL - summary
18. The elongin complex
19. In vivo properties of elongin A
20. Reduction of elongin A
21. dEloA is required for the transition to adulthood
22. dEloA re-localizes upon heat shock
23. dEloA is required for heat shock gene expression
24. Elongin A - summary
25. The role of COMPASS in methylation of histones
26. Set1 is essential for the methylation of histone H3
27. Microplate of viable yeast deletion mutants
28. GPS in S.cerevisiae (1)
29. GPS in S.cerevisiae (2)
30. RAD6 is essential for methylation of histone H3
31. The role of E3 in substrate specificity
32. Bre1 identified as E3-ligase
33. The role of E3 in substrate specificity
34. COMPASS association with transcribed region
35. Paf1 complex role in methylation by COMPASS
36. The model (1)
37. The model (2)
38. Transcriptional memory
39. The role of RNA pol ll elongation factors
40. Future studies

Topics Covered

• Transcriptional elongation
• Complexes involved
• Mechanisms regulating rate and efficiency of elongation on chromatin templates

Links

Series:

• Eukaryotic Gene Regulation

Categories:

• Cell Biology
• Genetics & Epigenetics

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on April 13, 2022

Financial Disclosures

• Dr. Ali Shilatifard has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.