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Navigable Slide Index

1. Introduction
2. Discovery of factor XI
3. Coagulation cascade
4. A diagram of the human factor XI polypeptide
5. Factor XI - gel filtration
6. Intrinsic pathway protease deficiencies
7. Tissue factor
8. Plasma coagulation and coagulation factor
9. Factor XI activation by thrombin on platelets
10. Factor XI activation on the platelets surface
11. Thrombin generation in platelet rich plasma
12. Fibrin clot resistance to fibrinolysis - assay
13. Fibrin clot resistance to fibrinolysis - results
14. Thrombin activatable fibrinolysis inhibitor (TAFI)
15. Summary: physiology of factor XI
16. Bleeding in factor XI deficiency
17. Mutations in factor XI
18. Bleeding in factor XI deficiency: types II and III
19. Factor XI deficiency - type II
20. Factor XI A4 domain mutations
21. Factor XI deficiency: types II and III
22. Over 100 different mutations identified
23. Factor XI deficiency
24. Autosomal dominant factor XI deficiency?
25. Factor XI deficiency: dominant mutations (1)
26. Factor XI deficiency: kindred
27. Factor XI deficiency: catalytic domain
28. In vitro transfection system assay
29. In vitro transfection system assay results
30. Mutations effect on the secretion of wt factor XI
31. Relative factor XI (%) in media and in lysates
32. Factor XI deficiency - dominant mutations (2)
33. Classification system for CRM factor XI deficiency
34. Summary: factor XI deficiency
35. Treatment: factor XI deficiency
36. Inhibitors: factor XI deficiency
37. Factor XI and thrombotic disease
38. Factor IX and factor XI deficient mice
39. Carotid artery occlusion: ferric chloride model
40. Carotid artery injury model
41. Factor XI deficient mice: ferric chloride model
42. Factor XI deficient mice: effect of aspirin/heparin
43. Summary: factor XI thrombotic disease

Topics Covered

• Discovery of coagulation factor XI
• Structure of factor XI
• Normal plasma coagulation
• Mechanisms for factor XI activation
• Inherited factor XI deficiency
• Factor XI in mouse thrombosis models

Links

Series:

• Protein Epidemiology

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice

Therapeutic Areas:

• Haematology

Talk Citation

Gailani, D. (2007, October 1). The physiology and pathology of coagulation factor XI [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/VKLQ1014.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on July 7, 2016

Financial Disclosures

• Dr. David Gailani has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.