Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Talk outline
3. Preface
4. Types of sample
5. Classical paradigm
6. Classical paradigm - 1st sampling stage
7. Classical paradigm - 2nd sampling stage
8. Classical paradigm - 3rd sampling stage
9. Classical paradigm - 4th sampling stage
10. Complex diseases
11. Linkage mapping
12. Association study samples
13. Purpose of association study
14. Information for association (1)
15. Information for association (2)
16. Two stage sampling
17. What should the first stage sample be?
18. Family samples
19. Pooled DNA samples
20. Case-control samples
21. Single stage sampling for GWA
22. Two stage sampling for GWA
23. Cost efficient two stages
24. Two stage sampling: Satagopan et al. (2002)
25. Two stage sampling: Satagopan et al. (2004)
26. Two stage sampling: Satagopan and Elston (2003)
27. Two stage sampling: Skol et al. (2006)
28. Two stage sampling: Wang H et al. (2006)
29. Strategies and challenges
30. Three/multistage design (1)
31. Three/multistage design (2)
32. Summary
33. References (1)
34. References (2)

Topics Covered

• Classical paradigm for rare monogenic diseases
• Multistage designs for association studies, common complex diseases
• Random and multiplex family samples, case-control samples
• Genetic epidemiology: segregation analysis, linkage analysis, association analysis
• Sampling to minimize cost
• Multiphase analysis to increase power, multiple comparisons

Links

Series:

• Genetic Epidemiology II

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Robert Elston has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.