Topics Covered
- Applications of statistical modelling of population admixture
- Genetic and environmental explanations for ethnic differences in disease risk
- Methods for finding genes that influence complex traits
- Exploiting admixture to map genes
- Statistical power of admixture mapping
- Advantages of admixture mapping in comparison with other approaches to finding disease susceptibility genes
- Methodological problems of extending linkage analysis of a cross to admixed human populations
- Statistical methods that allow linkage analysis of a cross to be extended to admixed humans
- Model for stochastic variation of ancestry on chromosomes inherited from an admixed parent
- Multipoint inference of ancestry at marker loci from genotypes
- Null hypothesis as graphical model
- Statistical approach to model fitting and hypothesis testing
- The score test algorithm
- Other model diagnostics: "Bayesian p-values"
- How many markers are required for genome-wide admixture mapping?
- Panels of ancestry-informative markers
- Other applications of statistical modelling of admixture
Links
Series:
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Talk Citation
McKeigue, P. (2007, October 1). Admixture mapping [Video file]. In
The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 15, 2022, from
https://hstalks.com/bs/606/.
Publication History
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Published on October 1, 2007
Financial Disclosures
- Dr. Paul McKeigue has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.