• Improving on "Natural" Rodent Antibodies
• 26 min
  1. The immunogenicity problem in antibody therapy

  • Prof. Herman Waldmann
• 32 min
  2. Antibodies by protein engineering

  • Prof. Sir Gregory Winter
• 60 min
  3. The generation of diversity in antibody genes

  • Prof. Michael Neuberger
• 51 min
  4. Innate immunity to retroelements by human AID/APOBEC3 proteins

  • Prof. Reuben Harris
• 36 min
  5. Fc receptors and antibody effector functions

  • Dr. Mike Clark
• 57 min
  6. Antibody engineering of Fc effector functions

  • Dr. Mike Clark
• 35 min
  7. Antibody engineering: beginnings to bispecifics and beyond

  • Dr. Ian Wilkinson
• Antibodies in Cancer Therapy
• 41 min
  8. Monoclonal antibodies and the ErbB system in human cancer

  • Prof. Mark Greene
• 71 min
  9. Checkpoint blockade in cancer immunotherapy

  • Prof. James Allison
• 45 min
  10. Monoclonal antibodies in haemato-oncology

  • Prof. Mark Cragg
• Diagnostic Antibodies
• 46 min
  11. Monitoring therapy with antibodies

  • Dr. Geoffrey Hale
• Cell Surface Glycoproteins on Cells of the Immune System
• 38 min
  12. Cell surface glycoproteins on cells of the immune system

  • Prof. Neil Barclay
• Antibodies as Immunosuppressants
• 29 min
  13. Monoclonal antibodies to induce therapeutic immunological tolerance

  • Prof. Herman Waldmann
• 29 min
  14. Antibodies to control or prevent type 1 diabetes

  • Dr. Robert Hilbrands
• 48 min
  15. Antibody therapy of multiple sclerosis

  • Dr. Alasdair Coles
  • Prof. Alastair Compston
• 42 min
  16. Monoclonal antibodies in the management of rheumatoid arthritis

  • Prof. John Isaacs
• 40 min
  17. Modern management of rheumatoid arthritis - with a focus on biologic therapies

  • Prof. John Isaacs
• 30 min
  18. Tolerance induction to clotting factors with monoclonal antibodies

  • Prof. Luis Graca
• Archived Lectures *These may not cover the latest advances in the field
• 26 min
  19. Alemtuzumab (Campath-1H) in therapy of CLL

  • Prof. Kanti Rai
• 71 min
  20. VEGF inhibitors for anti-angiogenic therapy

  • Prof. Kari Alitalo
  • Dr. Bronislaw Pytowski
• 26 min
  21. Human antibodies produced in mice

  • Dr. Marianne Bruggemann
• 52 min
  22. New strategies to prevent transplant rejection: from molecules to mice to monkeys to man

  • Prof. Christian Larsen
• 55 min
  23. CD20 antibodies in the targeting of B-cell malignancies and autoimmunity

  • Prof. Thomas Tedder
• 45 min
  24. Anti-IL-2 receptor antibodies as models for cancer therapy

  • Prof. Thomas Waldmann
• 58 min
  25. Anti TNF therapy in rheumatoid arthritis

  • Prof. Marc Feldmann
• 36 min
  26. Novel immunotherapeutic proteins: immunoligand

  • Prof. Terry Strom
• 21 min
  27. Diagnostic immunohistopathology

  • Prof. David Mason
• 56 min
  28. Antibodies in the control of type I diabetes

  • Prof. Lucienne Chatenoud
• 43 min
  29. The challenge of targeting toxins to tumors

  • Prof. Ben Seon
• 38 min
  30. Antibody depletion therapy in transplantation: implications for tolerance

  • Prof. Laurence Turka
• 36 min
  31. Antibodies as anti-virals

  • Prof. Dennis Burton

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Table of contents
3. Section 1: introduction
4. Structure function of PE, DT and ricin
5. Immunotoxins
6. Background and objectives
7. Toxins used for preparation of immunotoxins
8. Mode of action of immunotoxins
9. Advantages: immunotoxins vs. naked antibodies
10. Disadvantages: immunotoxins vs. naked antibodies
11. Impediments in the application of immunotoxins
12. Section 2: anti-angiogenic therapy
13. Tumors at different stages of angiogenesis
14. Endoglin (CD105)
15. Reactivity of anti-EDG with endothelium (1)
16. Reactivity of anti-EDG with endothelium (2)
17. Cross-reactivity of anti-EDG with endothelium
18. Complete inhibition of MCF-7 in SCID mice
19. Section 3: a pretreatment strategy
20. Turnover time of various tissues
21. Blood clearance of IgG in BALB/c mice
22. Pharmacokinetic parameters of IgG in mice
23. Cumulative mouse mortality
24. Effect of pretreatment on mice weight
25. Effects of SN6f-dgRA / naked SN6f injections
26. LD50 values of SN6f-dgRA injected mice
27. Section 4: reducing immunogenicity
28. Strategies for minimizing immunogenicity
29. Section 5: immunotoxins versus naked mAbs
30. Anti-EDG: an anti-angiogenic therapy for tumors
31. Anti-EDG: a vascular targeting therapy for tumors
32. Prolonged complete suppression by SN7-RA
33. Therapy of SCID mice by SN7 and SN7-RA
34. Section 6: conclusions
35. Conclusions

Topics Covered

• Generation of immunotoxins
• Mode of action of different immunotoxins
• Strategies to overcome the major impediments in the therapeutic application of immunotoxins to cancer patients
• Anti-endoglin monoclonal antibodies and immunotoxins
• Anti-angiogenic therapy of tumors
• Vascular targeting therapy of tumors
• Comparison between immunotoxins and naked antibodies in therapeutic application

Links

Series:

• Monoclonal Antibodies as Therapeutic Agents

Categories:

• Cancer
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Oncology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Ben Seon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.