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Printable Handouts
Navigable Slide Index
- Introduction
- Derivation of transgenic lines
- Introduced human Ig loci expressed in mice
- Ig heavy and light chain knock-out mice
- Human translocus integration in Ig KO mice
- Expression of human IgM in mice
- Analysis of Ab producing B-cells by flow cytometry
- Analysis of B-cell development
- The human antibody response
- Human anti-human Abs from immunized mice
- Pentameric IgM
- V-D-J junction and hypermutation in mice
- Fully human antibodies in pre-clinical trials
Topics Covered
- Immune development
- Human Ig loci
- Transgenesis
- Human antibody repertoires
- Monoclonal human antibodies
- Silencing mouse antibody production
- B-cell receptor structure
- Flow cytometry
- Therapeutic Ig
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Bruggemann, M. (2007, October 1). Human antibodies produced in mice [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 7, 2024, from https://doi.org/10.69645/ILUC6973.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Marianne Bruggemann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.