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1. The deep history of life
- Prof. Andrew H. Knoll
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2. The neutral and nearly neutral theories of molecular evolution 2
- Prof. Joseph P. Bielawski
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3. The neutral and nearly neutral theories of molecular evolution 1
- Prof. Joseph P. Bielawski
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4. The coalescent
- Prof. Peter Beerli
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5. Evolution of drug resistance
- Dr. Pleuni Pennings
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6. Trends in macroevolution
- Prof. Luke Harmon
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7. Social evolution
- Prof. Dustin R. Rubenstein
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8. Principles of phylogeography and landscape genetics
- Dr. Ryan Garrick
-
9. Evolutionary developmental biology
- Dr. Karen Sears
-
10. Biogeography: explaining the geographical distribution of organisms
- Prof. Alexandre Antonelli
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11. Evolutionary case study: the genomics of speciation in Heliconius butterflies
- Prof. Adriana D. Briscoe
-
12. Human evolution
- Prof. Vagheesh Narasimhan
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13. How do organisms evolve in response to global change?
- Prof. Erica Bree Rosenblum
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14. Conservation genomics: adaptation and gene flow
- Prof. Jacob Höglund
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15. Conservation genomics: genetic diversity and inbreeding
- Dr. Jacqueline Robinson
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16. Evolution of agriculture: the origin of our food crops
- Dr. Mona Schreiber
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17. Evolutionary medicine
- Prof. Stephen C. Stearns
Printable Handouts
Navigable Slide Index
- Introduction
- Environmental change is ubiquitous
- Species must be able to respond to environmental change
- Selection and evolution
- What is needed for adaptation?
- Is genetic variation higher in large or in small populations?
- Consequences of population declines
- Can small populations adapt?
- Selection at the nucleotide level
- Positive selection
- Selection is more efficient in large populations
- More mutations in large populations
- Purging: removal of genetic load
- Examples of purging from the wild
- Population genomics: critically endangered kākāpō
- Mutational load estimates for kākāpō
- Mutation load has two components
- Fixation load: mutational meltdown
- Small census size and demographic bottlenecks
- Slow versus rapid loss of genetic diversity
- Reduced genetic diversity in small populations
- Local adaptation: willow / red grouse
- Local adaptation
- Differentiation through drift (neutral markers)
- Differentiation in quantitative characters
- Local adaptation, drift or uniform selection
- Can small populations adapt?
- Population size
- Strategic plan
- Genetic rescue of small populations
- Outbreeding depression
- Genetics of outbreeding depression
- Bateson-Dobzhansky-Muller model
- Outbreeding depression: Arabidopsis thaliana
- Should Irish and British red grouse be admixed?
- Irish grouse: paler than British and Scandinavian
- Irish and British red grouse genomic analysis
- Should Bengal and Sumatran tigers be admixed or kept apart?
- Results: Bengal and Sumatran tigers
- Clouded Apollo in Sweden
- Swedish Clouded Apollo have low diversity
- Mitochondrial DNA
- Should populations be admixed?
- Assessing the risk of outbreeding depression
- Summary (1)
- Summary (2)
Topics Covered
- Conservation genomics
- Adaptation and gene flow
- Environmental change is ubiquitous
- Selection and evolution
- Genetic variation in large and small populations
- The extinction vortex
- Mutation, selection, and drift in large and small populations
- Purging and genetic load
- Local adaptation
- Genetic rescue vs. outbreeding depression
Talk Citation
Höglund, J. (2023, January 31). Conservation genomics: adaptation and gene flow [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/XUBL5812.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jacob Höglund has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Genetics & Epigenetics
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, my name is Jacob Hoglund.
I'm a professor of Ecology and
Genetics at Uppsala
University in Sweden.
It's a pleasure for me to
give this talk on
conservation genomics,
and my topic today is on
adaptation and gene flow.
I would like to say that
the title genomics could
actually be changed
to genetics because
the whole theory
rests on population genetics.
But of course, genomics is
more modern and gives you
more fine tuned data
that we can analyze
nowadays than we used
to be in the past.
0:37
I would like to begin
by this statement here:
environmental change
is ubiquitous.
That is that life on Earth
has and always will change.
If you want to find evidence
of that, like I do here,
you can go out to the hallway of
my department and
what you find there
in the staircase is shown in
this picture I took a
couple of days ago.
What you see is remnants of
Nautiloid cephalopods from
the lower middle
Ordovician of Sweden,
and my colleagues in the
paleontology department,
they suspect that this
stuff is from a quarry
at a place called
Brunflo, near Östersund
in central Sweden.
Of course, these
organisms do not exist in
Sweden nowadays, they went
extinct millions of years ago.
You'll see a T-Rex
replica that you
can find in the Evolution Museum
here at Uppsala University,
and of course, this
species doesn't roam
around the globe like
they used to in the past.
What this shows is
that organisms change
via four different
mechanisms basically.
These are mutation,
something called
genetic drift that I
would explain later,
gene flow and population
structure, and finally selection.
In my lecture today I will
go through and explain
how organisms adapt to
a changing environment.
The basic tenet of
this talk is that