Mucoadhesive drug delivery systems

Published on November 30, 2022   42 min

A selection of talks on Pharmaceutical Sciences

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Hello to everyone. My name is Panoraia Siafaka and I serve as an Assistant Professor at the Faculty of Pharmacy European University Cyprus located in Nicosia, Cyprus. Today, we will be talking about mucoadhesive drug delivery systems and their importance in the drug delivery field.
Let me give you now the outline of this presentation. First of all, we will be starting with the Introduction and history of mucoadhesive drug delivery systems. Later, we will go through the definition, theories, and mechanisms of mucoadhesion. Furthermore, the advantages, as well as disadvantages of mucoadhesive drug delivery systems, will be discussed. Moreover, we will continue with the role of bioadhesive polymers and other materials using a mucoadhesive drug delivery system. In addition, the types of mucoadhesive drug delivery systems and their application will be also reviewed. Finally, we will close the talk with advanced mucoadhesive dosage forms and the summary of this presentation.
It is well known that the mucosal layer acts as a barrier for the delivery of therapeutics to reach the target site for oral, nasal, as well as ocular, and other local administration routes. The clinically available formulations present limited effectiveness due to their poor mucus penetration. Therefore, the learning objectives of this presentation are to understand the complex mucus structure, the terms of bioadhesion and mucoadhesion, and overview the different mucoadhesive drug delivery systems. Before we discuss in detail about mucoadhesive dosage form, it's time for a little history lesson. In the last three decades, mucoadhesion has gained an enormous interest to prolong the residence time of mucoadhesive formulations through various mucosal routes in the drug delivery field; however, the concept of mucoadhesion arose more than 50 years ago. In 1947, a research team made various attempts to formulate a drug delivery system for the delivery of penicillin to the oral mucosa using gum tragacanth and dental adhesive powders. Two years later, in 1949 an adhesive penicillin ointment for topical application, composed of karaya gum, and a mixture of carboxymethylcellulose and petrolatum was introduced. In 1959, another formulation known as Orabase entered the clinical practice as a vehicle for the delivery of drugs to the oral mucosa. The formulation comprised of gelatin, pectin, and carboxymethylcellulose can stick on the mouth, and wet surfaces, and act as a protective film over mouth ulcers. Later years on, in 1968, a clinical evaluation of intraoral adhesive bandages was done, characterizing them as advanced oral wound healing systems due to their numerous advantages. Since the early '80s, the term mucoadhesion has had considerable attention in pharmaceutical technology. When the idea of mucoadhesion appeared as a new approach to extending the residence time of drugs used on the ocular surface. At present, various mucoadhesive drug delivery systems have been developed for oral, buccal, nasal, rectal, and vaginal routes, leading to both systemic and local effects.