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Safer opioid analgesics: targeting truncated Mu opioid receptor splice variants
Published on October 31, 2022 29 min
A selection of talks on Genetics & Epigenetics
Genetic counseling: preconception, prenatal, perinatal
- Prof. Aubrey Milunsky
- Tufts University School of Medicine, USA
Recent advances in the development of gene delivery technologies
- Dr. Takis Athanasopoulos
- GSK, UK
RNA modifications in human diseases: what, when and how?
- Prof. Chengqi Yi
- Peking University, China
Techniques to infer admixture using genome-wide autosomal DNA 1
- Dr. Garrett Hellenthal
- University College London, UK
My name is Ying-Xian Pan. I'm a Professor at the Department of Anesthesiology, Rutgers New Jersey Medical School. My research interests have long focused on the mechanism and the function of opioid actions, particularly as a route to Mu opioid receptors. Today, I will talk about one of our stories, how to translate our basic science into the development of normal opioid analgesics that are potent, but lack side effects.
This slide shows drug overdose deaths in the US in 2017. About 70K overdoses for all drugs and about 47K for opioid overdose deaths is more than two-thirds of all drug overdose deaths, which also is the driving force behind this steep increase in the death rate in recent years.
One main reason for opioid overdose deaths is opioid misuse through either prescription or illegal routes. This slide shows that in 2017, about 11 million people misused opioids and about 20 percent of the 2.1 million people developed opioid use disorder. However, the main reason for opioid misuse is pain-over 62 percent. What is pain?
The word pain comes from Latin, Peona or Greek Poine, meaning punishment or penalty. Based on the International Association for the Study of Pain, pain is defined as an unpleasant sensory and emotional experience associated with or resembling that is associated with actual or potential tissue damage or described in terms of such damage. Pain is subjective and protective, and is modified by developmental-behavioral, personality, and cultural factors. Pain is the most common symptom leading to physician contact. Pain is the main reason for opioid misuse contributing to the worldwide opioid epidemic.