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Printable Handouts
Navigable Slide Index
- Introduction
- Talk overview
- Retroviruses
- Deltaretroviruses
- Bovine leukemia virus (BLV)
- Leukemia, lymphoma and lymphosarcoma
- BLV transmission
- BLV transcripts
- The proteins encoded by the BLV transcripts
- Structural, enzymatic and regulatory proteins
- The BLV viral particle
- Bovine leukemia virus: viral replication
- Modes of viral replication
- Mandatory and dispensable genes
- BLV mutants (1)
- Infectivity and viral propagation
- Frequent deletions in the provirus
- Bovine leukemia virus: transmission
- Transmission
- Cell type specificity
- Bovine leukemia virus: pathogenesis
- Pathogenesis
- Differences between cattle and sheep
- Pathologies
- The Tax gene
- The Tax protein
- BLV mutants (2)
- Pathogenicity in vivo
- Bovine leukemia virus: cell dynamics
- BLV-induced leukemia and cell proliferation
- Ex vivo proliferation
- Lymphocyte dynamics: ex vivo proliferation
- Apoptosis
- Ex vivo: inhibition of apoptosis
- Lymphocyte dynamics: ex vivo apoptosis
- Chemotaxis
- Lymphocyte dynamics: ex vivo migration
- In vivo
- Kinetics of BrdU-labeled B-lymphocytes
- Lymphocyte dynamics: in vivo
- Proliferation occurs in the source
- Tracing B cells
- Canulation of lymphatics
- Direct determination of B-lymphocyte migration
- Lymphocyte dynamics: in vivo migration
- Turnover of blood B-lymphocytes
- Proliferation and death rates of the blood B-cells
- Dynamic parameters of blood B cells (1)
- Lymphocyte dynamics: lymphoid tissue vs. blood
- B-lymphocyte dynamics in vivo
- CFSE kinetic profile and splenectomy
- Dynamic parameters of blood B cells (2)
- Lymphocyte dynamics and splenectomy
- Bovine leukemia virus: therapy
- The viral promoter
- Efficient viral propagation and suboptimal promoter
- Activation of viral expression
- Transcriptional activation and chromatin acetylation
- Activation of LTR-directed gene expression
- Valproate induces apoptosis
- Valproate increases viral expression
- Valproate as a tool
- Therapeutic activity of valproate in leukemic sheep
- HTLV-1 and BLV: valproate therapy
- HTLV-1 (1)
Topics Covered
- Viral replication of bovine leukemia virus
- Transmission and pathogenesis in natural and experimental hosts
- Dynamics of cell accumulation
- Novel therapeutic approach
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Burny, A. and Willems, L. (2017, May 31). Bovine leukemia virus [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/ZHEF8721.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Arsene Burny has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
- Dr. Lucas Willems has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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Transcript
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0:04
We are presenting a lecture on bovine leukemia virus,
and we shall speak about virus replication,
transmission, pathogenesis, cell dynamics and therapy.
Bovine leukemia virus belongs to the retroviruses family.
0:18
Its genome is composed over single stranded RNA molecule,
which is flanked by two long terminal repeats.
The genome contains series of structural and enzymatic genes, gag, pol,
and env coding for the proteins required for the constitution of the viral particle.
As a retrovirus, BLV also encodes a reverse transcriptase,
an enzyme which is able to reverse transcribe the genomic RNA into a DNA molecule,
which is then called the provirus,
and this DNA can integrate into the chromosomal DNA of
the host cell by means of another enzyme, the integrase.
In fact, bovine leukemia virus belongs to the genus deltaretroviruses in which,
besides the genes that we had described before,
there are four other genes,
called TAX for transactivator of transcription,
REX for export of viral RNA molecules,
J4 and R3 are oncogenes and the regulatory genes.
The deltaretrovirus genus contains two main members,