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Printable Handouts
Navigable Slide Index
- Introduction
- Disclosures
- Outline of talk - vitamin D actions
- Views of vitamin D actions - classical view
- Calcium balance and bone homeostasis
- Vitamin D and calcium are vital as estrogen drops
- Vietnam AFC original crackers
- Vitamin D metabolic pathways (1)
- Views of vitamin D actions - expanded view
- Vitamin D metabolic pathways (2)
- Anti-cancer actions are highlighted in the press
- Beneficial actions presented on a milk carton
- Cancers in which vitamin D is protective
- Outlline of talk - sunlight, vitamin D and PCa risk
- Background: vitamin D and cancer
- Risk factors and vitamin D deficiency hypothesis
- PCa mortality rates and UV radiations in USA
- Outline of talk - local calcitriol production
- Vitamin D metabolic pathways (3)
- Importance of local production of calcitriol
- 2 alpha-hydroxylase activity in prostate cells
- Growth inhibition of prostatic epithelial cells
- 25(OH)D3 activity and 1 alpha-hydroxylase activity
- Prostate synthesis of 1,25(OH)2D from 25(OH)D
- Outline of talk - 24-hydroxylase activity level
- Differential sensitivity to calcitriol actions
- Liarozole
- Inhibition of 24-hydroxylase activity by liarozole
- Liarozole renders DU145 cells growth
- Effect of liarozole on 1,25(OH)2D3 half life
- VDR up-regulation by 1,25(OH)2D3 and liarozole
- Conclusions: 24-hydroxylase inhibitors
- Outline of talk - anti-cancer mechanisms
- Mechanisms of anti-cancer activity of 1,25(OH)2D3
- Vitamin D3 inhibits epithelial cells
- Effect of 1,25(OH)2D3 on proliferation rate
- Calcitriol and inflammation
- COX-2 actions and prostate cancer
- Inflammatory mechanisms in carcinogenesis
- COX-2 and PG induction of cancer
- Localization of COX-2 and recurrence probabilty
- Search for new target genes regulated by calcitriol
- Calcitriol exhibits three actions to inhibit PG action
- Three calcitriol actions to inhibit PG activity
- Calcitriol actions in PCa cells
- Potential synergy of calcitriol with NSAIDs
- Calcitriol and NSAIDs effects on PCa cells growth
- Outline of talk - results of vitamin D therapy in vivo
- Clinical trial of calcitriol and naproxen
- Calcitriol plus naproxen trial
- Change in PSADT
- Conclusions
- Progression from normal to PIA to PIN to PCa
- Calcitriol inhibits PIN formation in Nkx3.2
- Calcitriol blocks normal to high PIN conversion
- ASCENT results: randomized, double-blind study
- DN-101: ASCENT trial
- ASCENT: duration of overall survival
- Vitamin D role in prevention and treatment of PCa
- Acknowledgements
Topics Covered
- Vitamin D actions: classical view and expanded view
- Vitamin D metabolic pathways
- Vitamin D and cancers
- Vitamin D-deficiency hypothesis
- Sunlight, vitamin D and prostate cancer risk
- Importance of local production of calcitriol
- Importance of 24-hydroxylase activity level
- Differential sensitivity to antiproliferative actions of calcitriol
- Inhibition of 24-hydroxylase activity by liarozole
- Anti-cancer mechanisms
- Calcitriol and inflammation
- COX-2 actions and prostate cancer
- Inflammatory mechanisms in carcinogenesis
- COX-2 and PG induction of cancer
- Three calcitriol actions to inhibit PG activity
- Potential synergy of calcitriol with NSAIDs
- Results of vitamin D therapy in in vivo trials of prostate cancer
- Calcitriol and naproxen
- Genetic mouse model of PIN-HG-PIN
- High dose intermittent calcitriol plus docetaxol
Talk Citation
Feldman, D. (2007, December 1). Vitamin D and prostate cancer [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 24, 2024, from https://hstalks.com/bs/502/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. David Feldman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.