Registration for a live webinar on 'Neuroleptic malignant syndrome' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Potential metabolic fates of pyruvate
- Lactate transport
- Pyruvate dehydrogenase complex
- Importance of maintaining flux via PDC
- Impact of excessive flux via PDC
- Allosteric regulation of PDC
- Covalent regulation of PDC
- Mechanisms of activation of PDC
- Regulation of PDP isoforms
- Mechanisms of suppression of PDC
- PDK expression
- Site specificity of PDC phosphorylation
- Impairing PDC reactivation by PDK4
- PPAR-alpha
- PDK expression in Morris hepatoma 7800 C1 cells
- Regulation of PDK4 expression
- Consequence of a low PDC activity (liver)
- Anaplerosis and cataplerosis
- Pyruvate carboxylase
- Physiological roles of cataplerosis in liver
- Insulin secretion in relation to pyruvate handling
- Glucose/fatty-acid cycle - high lipid utilisation
- Upregulation of PDK expression
- Acute regulation of PDK by metabolites
- PDK isoforms change PDC activation sensitivity
- PGC-1alpha
- Regulation of skeletal muscle pyruvate disposition
- Skeletal muscle fuel handling
- Insulin resistance and metabolic inflexibility
- Insulin resistance modifies muscle PDK and PDC
- Consequences of PDK4 upregulation
- Disorders of pyruvate handling: PDC deficiencies
- Disorders of pyruvate handling: PC deficiencies
Topics Covered
- Potential metabolic fates of pyruvate
- Lactate transport
- Role of pyruvate dehydrogenase complex (PDC)
- Regulation of PDC
- Mechanisms of activation of PDC by pyruvate dehydrogenase phosphatases
- Pyruvate dehydrogenase kinase (PDK) expression and regulation
- Multi-site phosphorylation
- Transcription factors regulating PDK4 expression
- Anaplerosis and cataplerosis
- Pyruvate carboxylase
- Insulin secretion and action
- Glucose/fatty-acid cycle
- Consequences of PDK4 upregulation
- Disorders of pyruvate handling
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Sugden, M. (2007, October 1). Modifications of pyruvate handling in health and disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 13, 2024, from https://doi.org/10.69645/UTDT5839.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Mary Sugden has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.