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1. Introduction
2. ErbB receptor / ligand network
3. Ligand activated ERBB receptors (1)
4. ERBB receptors and intracellular signaling
5. Ligand activated ERBB receptors (2)
6. Signaling from ErbB2 containing heterodimers
7. ErbB2/ErbB4 heterodimers in embryonic growth
8. Activated ErbB2/ErbB4 heterodimers in heart
9. Ligand activated ERBB receptors (3)
10. ErbB2/3 hetrodimers and downstream signaling
11. ErbB2/ErbB3 heterodimers in embryonic growth
12. Structural studies of ERBB receptors
13. The extracellular region of ERBB receptors
14. EGF binding induces a conformational change
15. ErbB2 structure is similar to activated EGFR
16. ERBB receptors and cancer - background
17. ErbB2 detection in breast cancer
18. ERBB receptors and cancer (1)
19. ERBB receptors and cancer (2)
20. ERBB targeted therapeutics in clinical use
21. EGFR and human cancer
22. EGFR and lung cancer
23. Mutations in EGFR kinase domain
24. EGFR and human cancer
25. ErbB2 and human cancer
26. Autocrine / paracrine ERBB activation
27. Processing of EGF-related ligands
28. Proteases and processing of pro-ligands
29. ERBB targeted therapeutics in clinical use
30. Structure of recombinant antibodies
31. ERBB targeted therapeutics
32. ERBB RTKs and intracellular signaling in cancer
33. ErbB2 and Trastuzumab
34. Targeting ErbB2 blockes tumor cell proliferation
35. 4D5 blocks ErbB2 and Akt signaling
36. 4D5 blocks cyclin E/Cdk2 kinase activity
37. Targeting ErbB2 in cancer cells
38. Mechanisms proposed for Trastuzumab
39. ErbB2 and Trastuzumab
40. Trastuzumab and rational drug development
41. Trastuzumab efficacy
42. ErbB2 and Trastuzumab
43. Targeting ErbB2 blockes tumor cell proliferation
44. ERB ligands overcome anti-proliferative activity
45. Trastuzumab binds domain IV of ErbB2
46. Conclusions and perspectives

Topics Covered

• ERBB receptor/ligand network
• Activation and intracellular signaling
• Developmental roles for ERBB2 containing heterodimers
• ERBB receptor structure
• Molecular alterations of ERBB receptors in cancer
• Targeting ERBB receptors in cancer
• In vivo and in vitro studies describing how ERBB receptor blockade impacts on cancer
• Resistance of cancer cells to ERBB inhibitors

Links

Series:

• Signal Transduction via Protein Tyrosine Kinase Receptors

Categories:

• Biochemistry
• Cancer
• Reproduction & Development

Therapeutic Areas:

• Oncology

Talk Citation

Hynes, N. (2007, October 1). The epidermal growth factor receptor family: roles in development and cancer [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/MFMP8030.
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Publication History

• Published on October 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Prof. Nancy Hynes has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.