Hello. My name is Dr. Jessica Quimby and I'm
an associate professor at the Ohio State University.
I'm a specialist in Small Animal Internal Medicine,
and have previously performed PhD studying Feline Chronic Kidney Disease.
The topic of today's talk will be Feline chronic kidney disease:
pathophysiology, diagnosis and then staging of disease.
Through this process, we'll go through what our current state of knowledge
is about the pathophysiology of the disease in cats,
as well as how we diagnose it clinically and how the disease
is staged in order to help us better monitor these patients.
Chronic kidney disease has a well-described pathology and histopathology in cats.
It is consistent with tubulointerstitial disease.
What we see histopathologically is interstitial inflammation, tubular atrophy,
fibrosis, and then also secondary
glomerulosclerosis that forms as the disease progresses.
There are several pathologic processes that we think are
associated with these histopathologic changes in the cat.
And those likely include hyperfiltration, inflammation, hypoxia,
as well as oxidative stress,
and vascular damage to the tissues that
further compromise the functioning tissue that remains.
Interstitial fibrosis would be the end stage result of
the inflammation and tubular death that's happening within the kidney.
And in this particular slide we see a more normal,
healthy kidney in the left hand picture followed by a cat with later stage disease.
And in this particular picture,
the blue that you see is a trichrome stain.
This is representing the greater amount of fibrosis or scarring
that's happening within the kidney is particularly in diseased sections.
So in this right hand slide,
you see that there are some areas of
normal tubules in the upper right-hand part of that picture,
but the majority of the area is now taken over with fibrosis and
interstitial disease that has basically pushed aside the normal tubules.
This finding on histopathology is very common with cats with chronic kidney disease.