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Printable Handouts
Navigable Slide Index
- Introduction
- Disclosure
- CIndU diagnostic workup
- Symptomatic dermographism
- Dermographometers
- FricTest®
- TempTest®
- Therapeutic strategies
- The goal of CU treatment
- CU treatment algorithm
- Effects of sedating antihistamines
- Increasing antihistamine dose
- Treatment with omalizumab (1)
- Treatment with omalizumab (2)
- Mechanism of omalizumab
- Time to response to omalizumab
- The reduction in dermal FcεRI+ cells
- Omalizumab as treatment of CIndU
- Omalizumab as treatment of SD
- Omalizumab works in SD
- Omalizumab retreatment
- High IgE levels are good
- Low IgE levels are bad
- Ligelizumab vs omalizumab
- The future of CSU treatment
- GA2LEN UCAREs
- Chronic urticaria registry
- Dermatological Allergology
Topics Covered
- CIndU (Chronic Inducible Urticaria) diagnostic workup
- Symptomatic dermographism
- Tests to identify CIndU
- Therapeutic strategies of chronic urticaria (CU)
- CU treatment algorithm
- Treatment with omalizumab
- Ligelizumab vs. Omalizumab
- Future treatments
Links
Series:
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Therapeutic Areas:
Talk Citation
Maurer, M. (2024, July 17). Chronic spontaneous and inducible urticaria 2 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/PDOK2658.Export Citation (RIS)
Publication History
Financial Disclosures
- Professor Maurer has received research funding from Deutsche Forschungsgemeinschaft (DFG), EU (FP7, COST), European Centre of Allergy Research Foundation (ECARF), Urticaria Network e.V. (UNEV), Bayer, Leo, Novartis, Riemser, and Uriach. He is a speaker and/org advisor for Allakos, Almirall Hermal, Bayer, BioCryst, Dyax, FAES, Genentech, Leo, Merckle Recordati, Moxie, MSD, Novartis, Pharvaris, Riemser, Sanofi Aventis, Shire, Takeda, Tribute Pharmaceuticals, UCB, and Uriach.
Chronic spontaneous and inducible urticaria 2
Other Talks in the Series: Allergy - From Basics to Clinic
Transcript
Please wait while the transcript is being prepared...
0:00
Hello. My name is Marcus Maurer,
and I'm very happy that you have the time to join us in
our review of chronic spontaneous and chronic inducible urticaria.
We will talk about chronic inducible urticaria and
the diagnostic workup of chronic inducible urticaria,
and end up with therapeutic approaches for
patients with chronic spontaneous and chronic inducible urticaria.
0:27
Let's move from chronic spontaneous urticaria to chronic inducible urticaria.
Chronic inducible urticaria is characterized by the presence of triggers,
so what we should do in
the diagnostic workup is we should confirm the trigger that is suspected,
we should measure the threshold in individual patients,
and assess and monitor their control and their disease activity.
0:54
How do we do that? The best question to ask
patients with chronic urticaria is to ask them,
can you make your wheals come?
Is there anything you can do right now to make a wheal come?
If patients tell us that they can make wheals come by scratching their skin,
then we scratch their skin.
We want to confirm that this is a relevant trigger,
and it's enough to do that with a pen or a wooden spatula.
When we make a wheal by doing this,
we have diagnosed chronic inducible urticaria,
we have diagnosed symptomatic dermographism.
1:31
The guidelines ask us to test how hard this trigger needs to be on the skin,
how hard patients need to scratch in order for their wheals to come.
This is assessed by the help of dermographometers.
There are different types of dermographometers,
and I'm showing you two different ones here.
What they have in common is that they are tools to scratch the skin of patients.