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- Introduction to Calcium Signaling
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72 min
1. Introduction to cellular calcium signaling- Dr. Martin Bootman
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20 min
2. Monitoring Ca2+ concentration in living cells- Dr. Marisa Brini
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30 min
3. Cell boundary theorem- Prof. Eduardo Ríos
- Calcium Influx
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19 min
4. Arachidonic acid and store-independent Ca2+ entry- Dr. Luca Munaron
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34 min
5. Voltage-dependent calcium channels- Prof. Annette Dolphin
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34 min
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37 min
7. Intracellular Ca2+ signaling: calcium influx- Prof. Anant Parekh
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60 min
8. Molecular identification of the CRAC channel- Prof. Michael Cahalan
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35 min
- Calcium Release
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53 min
10. The InsP3 receptor calcium release channel- Prof. J. Kevin Foskett
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31 min
11. Molecular biology of ryanodine receptors: an overview- Dr. Christopher George
- Prof. F. Anthony Lai
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57 min
12. cADPR and NAADP: messengers for calcium signalling- Prof. Antony Galione
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43 min
13. Ryanodine receptors and cardiac function- Prof. David Eisner
- Calcium Efflux and Sequestration
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45 min
14. Sodium-calcium exchange- Prof. John Reeves
- Organelle Calcium
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42 min
15. Regulation and role of mitochondrial Ca2+ homeostasis- Prof. Rosario Rizzuto
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54 min
16. Peroxisomes and Golgi apparatus as players in Ca2+ homeostasis- Dr. Paola Pizzo
- Dr. Alex Costa
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34 min
17. Ca2+ dynamics between mitochondria and the endoplasmic reticulum- Dr. Wolfgang Graier
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26 min
18. Nuclear calcium signaling- Dr. Oleg Gerasimenko
- Dr. Julia Gerasimenko
- Spatiotemporal Calcium Signals
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54 min
19. Regulation of intracellular calcium signaling, localized signals and oscillations- Prof. Barbara Ehrlich
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43 min
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41 min
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49 min
- Calcium Effectors
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34 min
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41 min
24. Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization- Prof. Dermot Cooper
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32 min
25. Calcium and transcription-coupling- Dr. Karen Lounsbury
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50 min
26. Cellular calcium (Ca2+) buffers- Prof. Dr. Beat Schwaller
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24 min
27. Extracellular calcium signaling- Dr. Aldebaran M. Hofer
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50 min
28. Ca2+, fertilization and egg activation- Prof. Karl Swann
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24 min
29. Calcium regulation of transcription in plants- Prof. Hillel Fromm
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34 min
30. Mechanisms regulating STIM expression and function in Ca2+ signaling- Dr. Jonathan Soboloff
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46 min
31. Dynamic signal encoding in the S. cerevisiae calcium response- Dr. Chiraj Dalal
- Calcium and Disease
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43 min
32. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease- Prof. Laura del Senno
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28 min
33. Ca2+ alterations in familial Alzheimer's disease (FAD)- Dr. Paola Pizzo
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38 min
34. Pancreatitis and calcium signaling- Prof. Ole Petersen
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47 min
35. Mechanism-based therapies for heart failure and cardiac arrhythmias- Prof. Andrew Marks
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46 min
36. Genetic defects and calcium- Prof. Tullio Pozzan
- Archived Lectures *These may not cover the latest advances in the field
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31 min
37. Calcium, calmodulin and calcineurin- Prof. Stephen Bolsover
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34 min
38. Calcium flickers steer cell migration- Prof. Heping Cheng
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28 min
39. Automated Ca2+ imaging of chemosensory neurones in C.elegans- Dr. Nikos Chronis
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46 min
40. Ca2+ and the regulation of small GTPases- Prof. Peter Cullen
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35 min
41. Genetically encoded Ca2+ indicators: molecular scale measurements in mammals in vivo- Dr. Michael I. Kotlikoff
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35 min
42. Capacitative (store-operated) calcium entry- Dr. Jim Putney
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47 min
43. The molecular biology of the inositol trisphosphate receptor- Dr. Randen Patterson
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50 min
44. Coordinated Ca2+ release from intracellular Ca2+ stores- Prof. Ole Petersen
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45 min
45. The plasma membrane calcium pump: biochemistry, physiology and molecular pathology- Prof. Ernesto Carafoli
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60 min
46. The calcium saga: a matter of life and death- Prof. Pierluigi Nicotera
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22 min
47. Ca2+ efflux and Ca2+ signals- Dr. Anne Green
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31 min
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58 min
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26 min
50. Modeling Ca2+ signals- Dr. David Friel
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- The polycystic kidney disease (PKD)
- Clinical aspects of ADPKD
- Genetic aspects of ADPKD
- PKD mutations are somatically recessive
- The products of PKD1 and PKD2 : polycystins
- Polycystin (1)
- Polycystin (2)
- Properties of the PC2 channel
- PC1 and PC2: a receptor channel complex
- Subcellular localization of PC1 and PC2
- The PC1 and PC2 complex is conserved
- Primary cilium and cystic kidney disease
- Mechanosensory function of PC1/PC2 complex
- PC1 and PC2 signaling
- PC1, PC2 and calcium homeostasis
- PC1, PC2 and calcium levels in kidney cells
- PC1 and endoplasmic reticulum calcium uptake
- PC1 tail expression and NFAT activation
- PC1, cytoplasmic Ca levels and cell proliferation
- PC1 expression and cell proliferation
- Cross-talk between calcium and cAMP signaling
- Polycystin calcium signaling
Topics Covered
- Clinical and genetic aspects of polycystic kidney disease
- The polycystins (PC1, PC2)
- The PC2 channel
- PC1 and PC2 subcellular location and interaction
- Mechanosensory function of the ciliary PC1/PC2 complex
- PC signaling and calcium homeostasis
- PC1, calcium levels and cell proliferation
- PC1, cAMP signaling and cell proliferation
- PCs and physiopathologic calcium signaling
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
del Senno, L. (2007, October 1). Polycystins, calcium signaling and pathogenesis of polycystic kidney disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/ZQAE6412.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Laura del Senno has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Polycystins, calcium signaling and pathogenesis of polycystic kidney disease
Published on October 1, 2007
43 min
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