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1. Introduction
2. Ca regulation of the Ras binary switch
3. Post-translational modifications target Ras (1)
4. Molecular entities coupling Ca to Ras activation
5. Ca regulated Ras GEFs
6. Ras: regulation of the binary switch by Ca (1)
7. Mammalian Ras GAPs
8. The tandem C2 domains of RASAL and CAPRI
9. CAPRI and RASAL recruitment induction by Ca
10. CAPRI and RASAL activated as Ras GAPs
11. Ins(1,4,5)P3-mediated Ca elevation
12. CAPRI and RASAL distinct aspects of Ca code
13. CAPRI and RASAL resposes to Ca signals
14. CAPRI PH domain function
15. CAPRI: a combinatorial sensor
16. CAPRI and RASAL modulate multiple signales (1)
17. Ca regulated Ras GEFs work on multiple GTPases
18. CAPRI and RASAL modulate multiple signales (2)
19. Ras: regulation of the binary switch by Ca (2)
20. Temporal aspects of Ca coupling to Ras activation
21. Ca clamp: Ca and Ras signaling integration
22. [Ca]i oscillations effect in HeLa cells
23. [Ca]i oscillations frequency in HeLa cells
24. Raichu-Ras: imaging Ras activation in living cells
25. Raichu-Ras: imaging Ras activation in PC12 cells
26. Ca clamp-induced Ca oscillations in PC12 cells
27. Sustained Ca elevation effect in PC12 cells
28. Ca as a messenger allowing Ras activation
29. Post-translational modifications target Ras (2)
30. Ca as a messenger coupling cell-surface-R to Ras
31. Ca/CaM-induced translocation of K-Ras in neurons
32. Ca coupling to Ras in physiology and disease
33. Ca coupling to GTPases in synaptic plasticity
34. Ca/Ras complexes associated with the NMDA-R
35. Ca/Ras coupling in synaptic plasticity (1)
36. Ras and Rap role in AMPA-R trafficking
37. CAPRI and RASAL: enriched in the CA regions
38. Ca/Ras coupling in synaptic plasticity (2)
39. Ca and the regulation of small GTPases
40. Acknowledgments
41. Dr. Peter Lockyer

Topics Covered

• Introduction to small GTPases
• Ras as a GTPase subfamily
• Molecular entities, Ras GEFs and Ras GAPs, that couple Calcium to Ras activation
• Temporal aspects of Calcium coupling to Ras activation, using the Calcium-regulated Ras GAPs CAPRI and RASAL as examples of amplitude and frequency Calcium sensors
• Calcium as a messenger allowing Ras activation on endomembranes
• Calcium coupling to Ras in physiology and disease

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Peter Cullen has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.