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1. Introduction
2. Overview of Ca role and function
3. Outline (1)
4. Outline (2)
5. Example: Ca signals - step (a)
6. Example: Ca signals - step (b)
7. Steps in constructing Ca signaling models
8. Step a: define the 'dependent variables'
9. Identifying the variables to be considered
10. Step b: describe how variables change with time
11. Ca dynamics and total Ca flux
12. In real cells most of the Ca is bound
13. Fast buffering approximation
14. Simplification of Ca dynamics
15. Fast buffering approximation for multiple buffers
16. Step c: separate total Ca fluxes into components
17. Step d: describe functionality of fluxes
18. Step e: integrate the resulting differential equations
19. Qualitative properties of Ca dynamics
20. Steady-state properties
21. Responses to stimulation
22. Methods for analyzing Ca handling properties
23. Measuring the total cytoplasmic Ca flux
24. Measuring components of the total Ca flux (1)
25. Measuring components of the total Ca flux (2)
26. Characterizing cytoplasmic Ca buffering strength
27. Developing a model of Ca dynamics
28. Cytoplasmic Ca buffering strength
29. Developing a model of Ca dynamics: case (a)
30. Developing a model of Ca dynamics: case (b)
31. Summary and conclusions
32. Reading

Topics Covered

• Introduction to quantitative descriptions of Calcium signaling
• Examples of Calcium signals in sympathetic neurons
• Steps in constructing Calcium signaling models
• Qualitative properties of Calcium dynamics
• Methods for quantifying Calcium handling in intact cells
• Analysis of Calcium dynamics in sympathetic neurons

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Dr. David Friel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.