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Navigable Slide Index

1. Introduction
2. Na/Ca exchange (NCX) - overview
3. NCX and Ca homeostasis
4. Energetics of Na/Ca exchange
5. NCX is bi-directional
6. K-dependent Na/Ca exchange: NCKX
7. A brief history of Na/Ca exchange
8. NCX exchanger families
9. NCX1 protein
10. Splice variants of NCX1
11. Helix packing of NCX1
12. Consecutive reaction mechanism
13. Overview of NCX regulation
14. PIP2 blocks Na-dependent inactivation
15. PIP2 interacts with XIP
16. Regulatory Ca binding sites
17. Persistent Ca activation
18. Anomalous Ca regulation in drosophila
19. Squid axon Na/Ca exchanger
20. NCX and cardiac myocyte physiology
21. Cytosolic Na and cardiac contractility
22. NCX expression studies
23. NCX and cardiac pathophysiology
24. NCX inhibitors
25. NCX and hypertension?
26. Higher order NCX functions

Topics Covered

• The definition and thermodynamic driving forces for Na/Ca exchange and the historical development of the field
• The molecular biology of Na/Ca exchange family members
• The regulation of Na/Ca exchange
• The physiological functions of Na/Ca exchange in cardiac physiology, hypertension and higher neural functions

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. John Reeves has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.