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Printable Handouts
Navigable Slide Index
- Introduction
- Importance of intracellular [Ca]
- Ca is a life or death signal
- Calcuim concentration controls may processes
- The calcium specificity problem
- Calcium specificity problem - explanations
- Shape/kinetics of a Ca signal
- Calcium distribution
- Consequense of electrochemical Ca gradient
- Plasma membrane permeability to Ca
- Calcium entry channels
- The two major Ca-selective channels
- Techniques to study Ca channels
- Voltage-operated Ca channels - VOCC
- VOCC characteristics
- Subtypes of VOCC
- Evidence for sub-types of VOCC
- VOCC - biophysics - current-voltage relationship
- VOCC - biophysics - rate of inactivation
- VOCC - biophysics - single channel conductance
- VOCC - pharmacology
- VOCC - molecular biology
- Structure of VOCC
- Beta subunit effects on inactivation
- Topology of VOCC
- Analysis of the primary amino acid sequence
- Why are there so many VOCCs?
- Not all VOCCs add to neurotransmitter release
- Developmental changes in VOCC function
- Ca-dependent gene expression
- Non-channel functions of VOCC
- Signal transduction
- Anchoring protein
- Store-operated channels: SOC
- SOC: activated by store depletion
- Store depletion under physiological conditions
- CRAC channels
- CRAC channels - non-excitable cells
- Features of Ca current through CRAC channels
- Properties of I-CRAC
- I-CRAC - very selective for Ca
- Information conveyed from stores to channels
- Model: Ca release opens CRAC channels
- Key point
- Key signal - calcium sensor within the stores
- Vesicular fusion model
- Conformational coupling model
- Diffusible messenger model
- Stromal interaction molecule - STIM
- Some unresolved questions on SOC
Topics Covered
- Importance of intracellular calcium in cell activation
- Sources of intracellular calcium
- Key role for calcium channels in the plasma membrane
- Voltageoperated calcium channels
- Sub-types of voltage-operated calcium channels
- Structure of voltage-operated calcium channels
- Functions of voltage-operated calcium channels
- Local calcium signals drive cellular responses
- Store-operated calcium channels
- Properties of store-operated channels
- CRAC channels
- Gating of CRAC channels
Talk Citation
Parekh, A. (2007, October 1). Intracellular Ca2+ signaling: calcium influx [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 7, 2024, from https://doi.org/10.69645/ZVOM7415.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Anant Parekh has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.