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- Part 1 – Introduction and Control
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1. Introduction to neglected tropical diseases
- Prof. David Molyneux, CMG
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2. Eradication, elimination and control of neglected tropical diseases
- Prof. David Molyneux, CMG
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4. Neglected tropical diseases and environment, climate change and ecology
- Prof. Jürg Utzinger
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5. Neglected tropical diseases (NTDs) and vector control
- Prof. Charles Wondji
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6. Importance of communities in neglected tropical disease programmes
- Dr. Alison Krentel
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7. Monitoring, evaluation, research, learning and adapting for NTD programs
- Ms. Katie Zoerhoff
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8. Understanding treatment coverage in mass drug administrations
- Dr. Margaret Baker
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9. One health challenges of zoonotic NTDs
- Prof. Eric Fèvre
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11. NTD-related disease management, disability and Inclusion (DMDI)
- Dr. Wim H van Brakel
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12. NTDs mapping for effective programmes 1
- Prof. B.E.B. Nwoke
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13. NTDs mapping for effective programmes 2
- Prof. B.E.B. Nwoke
- Part 2 – NTD Diseases
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15. Mycobacterium ulcerans disease: Buruli Ulcer
- Prof. Richard Odame Phillips
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16. Dengue: biology, diagnosis and pathology
- Prof. Emeritus Duane J. Gubler
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17. Dengue: epidemiology, prevention and control
- Prof. Emeritus Duane J. Gubler
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18. Onchocerciasis (River Blindness) 1: the parasite, vector, disease and treatment
- Dr. Adrian Hopkins, MBE
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19. Onchocerciasis (River Blindness) 2: control and elimination
- Dr. Adrian Hopkins, MBE
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20. Schistosomiasis
- Prof. Russell Stothard
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21. Neglected tropical diseases caused by tapeworm infections
- Dr. Wendy Harrison
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22. Guinea worm: a case study of an eradication programme
- Prof. David Molyneux, CMG
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23. Elimination of lymphatic filariasis: adapting to reach the end game
- Dr. Patrick Lammie
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24. Leprosy: clinical features and treatment
- Prof. Diana N.J. Lockwood
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25. Leprosy: epidemiology, pathology, immunology, prevention of disability and stigma
- Prof. Diana N.J. Lockwood
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26. Visceral leishmaniasis control
- Dr. Koert Ritmeijer
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27. Overview of trachoma Part 1
- Dr. Paul Emerson
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28. Overview of trachoma Part 2
- Dr. Paul Emerson
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29. Eliminating human rabies deaths: rabies as a disease and a global burden
- Prof. Sarah Cleaveland, OBE, FRS
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30. Eliminating human rabies deaths: targeting the elimination of rabies
- Prof. Sarah Cleaveland, OBE, FRS
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31. Human African trypanosomiasis
- Prof. Susan Welburn
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32. Chagas disease
- Prof. Peter Hotez
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33. Food-borne trematodes
- Prof. Russell Stothard
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34. Yaws: past and present eradication efforts
- Prof. Oriol Mitjà
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35. Tropical snakebite
- Prof. Robert Harrison
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36. Introduction to podoconiosis
- Prof. Gail Davey
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37. Scabies
- Prof. Andrew Steer
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38. Mycetoma
- Prof. Ahmed Hassan Fahal
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39. Loiasis: African eye worm
- Dr. Louise A. Kelly-Hope
- Part 3 – Enteric Protozoan Parasites
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40. The ‘neglected enteric protists’: Cryptosporidium, Giardia and Entamoeba
- Prof. Sitara Ajjampur
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41. Cryptosporidium and cryptosporidiosis
- Dr. Kevin Tyler
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42. Toxoplasma gondii
- Prof. Geoff Hide
Printable Handouts
Navigable Slide Index
- Introduction
- Baylor College of Medicine
- National School of Tropical Medicine, Texas
- Neglected tropical diseases
- Chagas disease
- Numbers according to the GBD 2017
- Economic impact of Chagas disease
- Geographic Distribution of Chagas Disease
- Highest prevalence rates of Chagas disease
- Where does Chagas disease occur? (WHO)
- Three major drivers of 21st century NTDs
- Venezuela
- “The poorest of the rich” in G20 economies
- Blue marble health: G20 + Nigeria
- Globalization of Chagas disease
- Chagas disease transmission in Texas
- Trypanosoma cruzi pathogenesis
- Trypanosoma cruzi distribution
- Host cell invasion
- Life cycle of Trypanosoma cruzi
- Modes of transmission
- Acute Chagas disease
- Chronic Chagas disease
- Indeterminate vs. determinate
- Chagasic cardiomyopathy
- Chagasic cardiomyopathy: Kushnir classification
- Chagasic digestive disease
- Diagnosis
- Treatment (1)
- Treatment (2)
- The Chagas Coalition
- New chemical entities
- Therapeutic Chagas disease vaccine
- Prevention
- Thank you!
Topics Covered
- Introduction to Chagas disease
- Life history stages of Trypanosoma cruzi
- Epidemiology and impact
- Pathogenesis, life cycle and transmission
- Chronic and acute infection
- Symptoms, diagnosis, treatment and prevention
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Hotez, P. (2024, August 1). Chagas disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 24, 2025, from https://doi.org/10.69645/CXVE7318.Export Citation (RIS)
Publication History
Financial Disclosures
- The speaker is an inventor on some non-revenue generating patents for neglected disease vaccines.
HSTalks is pleased to grant unrestricted complimentary access to all lectures in the series Neglected Tropical Diseases. Persons not at a subscribing institution should sign up for a personal account.
A selection of talks on Infectious Diseases
Transcript
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0:00
Hello. My name is Peter Hotez.
I'm a professor at the Baylor College of Medicine.
I'm Professor of Pediatrics,
Molecular Virology, and Microbiology.
I'm also a dean of our National School of Tropical Medicine.
0:18
Our School of Tropical Medicine is relatively new.
It began in 2011.
The goal is to create a North American equivalent to
your wonderful Liverpool and London Schools of Tropical Medicine in the United Kingdom.
0:36
We're based in Houston, Texas.
Our National School of Tropical Medicine is part of
this extraordinary Texas Medical Center,
which is really a 'medical city',
maybe the world's first medical city that's comprised of
over 60 institutions and a 100,000 employees
who do everything big in Texas of course and
that includes Baylor College of Medicine and Texas Children's Hospital.
It also includes the MD Anderson Cancer Center.
Our goal as the National School of Tropical Medicine is to harness
the research and training strengths of
this amazing Texas Medical Center to develop new technology for the diseases of poverty.
1:18
Today, we're going to be speaking about Chagas disease,
which is one of 20 so-called neglected tropical diseases, or NTDs.
This is a term and a framework that we helped develop in the early 2000s
to refer to this group of tropical infections that are highly prevalent among the poor.
They represent the most common afflictions of people living in poverty.
They tend to be chronic and disabling conditions.
I sometimes refer to them as the most important diseases you've
never heard of and indeed that's a major subject of this course.
An important element of these diseases,
is they both occur in the setting of poverty,
but they're also a self cause of poverty because of
their debilitating effects on worker productivity,
childhood development, and pregnancy outcome.
On the right, I'm showing you a book I wrote
beginning in the 2000s and now it's gone into its second edition,
which you can refer to to get overviews of these neglected tropical diseases,
including today's subject on Chagas disease.
The book has also now been translated into Japanese.