Multiple myeloma: an overview

Published on February 28, 2019   37 min

A selection of talks on Haematology

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Good morning. I am Dr. Parameswaran Hari, a professor of medicine at the Medical College of Wisconsin in Milwaukee Wisconsin, United States. The goal today is to discuss the topic of "Multiple Myeloma" and give you a broad overview of this disease.
We'll do this in sequence. We'll talk with the historical context of multiple myeloma and its epidemiology. We'll talk about the pathology manifestations and the spectrum of this disease and it's natural history. Then we will go into diagnosis and investigations that are needed to be performed on patients with myeloma. We'll discuss treatment goals, mode of care. Treatment itself will be subdivided into topics such as; transplantation, maintenance, and treatment of relapse of multiple myeloma.
Multiple myeloma as a disease has been present for many, many centuries. There's evidence from the ancient Egyptians and the tombs in Egypt that multiple myeloma may have been present in some of the people who are buried there. In the United States and among the Native American skeletons, we have evidence of multiple myeloma dating back at least to 200 to 900 AD. This picture is of a skull of a 25-year-old female Native American person with lytic lesions that you can see as small holes in the skull bones that's estimated to be between 200 to 900 AD.
The first modern description of myeloma comes from 1844. This was reported in London and the publication is attached here with Dr. Samuel Solly of London, United Kingdom described two female patients with multiple bone fractures which he called "Mollities Ossium" or melting bones. The case that was reported extensively is that of a lady named Sarah Newbury who is historically credited as the first patient with a reported case of myeloma.