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- Part I. General subjects
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1. Need for drug delivery systems 1
- Prof. Ana Catarina Silva
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2. Need for drug delivery systems 2
- Prof. João Nuno Moreira
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3. Routes of drug delivery
- Prof. Dr. Sven Stegemann
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4. Transporters in drug delivery
- Dr. Pravin Shende
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5. The theory and applications of controlled release principles
- Dr. Michael J. Rathbone
- Part II. Routes for drug delivery
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6. Oral drug delivery
- Dr. Vineet Kumar Rai
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7. Transdermal drug delivery
- Prof. Sabine Szunerits
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8. Pulmonary drug delivery
- Prof. Anthony J. Hickey
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9. Gastrointestinal drug delivery
- Prof. Susan Hua
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10. Mucoadhesive drug delivery systems
- Dr. Panoraia I. Siafaka
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11. Ocular drug delivery
- Prof. Emily Dosmar
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12. Vaginal and uterine drug delivery
- Prof. José Luis Arias Mediano
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13. Drug-eluting implants
- Dr. Aliasger K. Salem
- Part III. Materials for drug delivery
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14. Polymers as nanocarriers for controlled drug delivery
- Prof. Dr. Marcelo Calderón
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15. Polymeric gels for drug delivery
- Dr. G. Roshan Deen
- Ms. Dora Safar
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16. Liposomes as a drug delivery system
- Dr. G. Roshan Deen
- Ms. Bushra Hasan
- Ms. Renad AlAnsari
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17. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)
- Prof. Ana Catarina Silva
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18. Micellar drug delivery
- Prof. Francesco Cellesi
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19. Nanocrystals in drug delivery
- Prof. Eliana Souto
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20. Layer-by-layer assemblies for drug delivery
- Prof. Szczepan Zapotoczny
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21. Inorganic nanostructured interfaces for therapeutic delivery
- Prof. Tejal Desai
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22. Inorganic porous drug delivery carriers
- Prof. Jessica Rosenholm
- Part IV. Specifics of drug delivery
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23. Delivery of genes and nucleotides
- Prof. Esam Yahya
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24. Vaccine delivery
- Prof. Sevda Şenel
- Part V. Drug delivery in various diseases
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25. Drug delivery for cancer therapeutics
- Prof. Tejraj Aminabhavi
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26. Nanomedicines for brain diseases
- Prof. Giovanni Tosi
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27. Drug delivery to the colon
- Prof. Susan Hua
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28. Role of the lymphatic system in drug absorption
- Dr. Kishor M. Wasan
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Definition of a controlled release product
- Controlled release principles
- Controlled release technologies/systems
- Immediate vs. controlled release drug
- Drawbacks to controlled release drug delivery
- Controlled release physicochemical principles
- Biological factors affecting controlled release
- Formulation approaches
- Diffusion controlled release approach
- Reservoir devices (solid & porous membranes)
- Control of release: reservoir devices
- Reservoir device issues (burst & lag)
- Matrix (monolithic) devices
- Higuchi square root of time model
- Control of release: matrix (monolithic) devices
- Biodegradable systems
- Osmotic systems
- Swellable matrix systems
- Release of drugs from swellable systems
- Applications (examples) of human products
- Geomatrix® technology
- NuvaRing vaginal ring technology
- Implanon contraceptive implant
- NicoDerm QC clear patch
- Bimatoprost ocular ring technology
- Veterinary products using controlled release
- TimeCapsule
- Ivomec SR Bolus
- Captec capsule
- CIDR intravaginal cattle insert
- Books about controlled release principles
Topics Covered
- Definition of a controlled release (CR) product
- Introduction to controlled release drug delivery
- Advantages and disadvantages of formulating a drug into a CR product
- Formulation approaches and mechanisms of drug release
- Applications (examples) of controlled release products in the human field
- Applications (examples) of controlled release products in the veterinary field
Talk Citation
Rathbone, M.J. (2018, November 29). The theory and applications of controlled release principles [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 26, 2024, from https://doi.org/10.69645/CCRM3499.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Michael J. Rathbone has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Pharmaceutical Sciences
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Mike Rathbone.
Today, I'm going to give you an introduction to
the theory and applications of controlled release principles.
This presentation was compiled by myself and Diviya Santhanes.
0:16
This presentation will start with the definition of a controlled release product.
It will then go on to give
an introduction to controlled release drug delivery by looking at
the advantages and disadvantages of formulating a drug into a controlled release product.
Later in the presentation,
the theory of a controlled release product will be over-viewed and some of
the formulation approaches and their mechanisms of release will be examined.
Now, controlled release products can be found in many fields.
Towards the end of this presentation,
we will show you some applications of controlled release products.
This will include controlled release products used
in both the human and veterinary fields.
1:01
A simplified definition for a controlled release product is a dosage form,
which is designed to release a drug at
a predetermined rate for a prolonged period of time.
This process is a deliberate act on the part of the formulator,
through prudent selection of ingredients and/or physical design,
to control the rate of release of the drug from the depths each form,
for periods far longer than immediate release products exhibit.
Controlled release products are available for all routes of
drug delivery and can be developed for human use,
animal use and consumer and diversified uses, including agriculture.