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Printable Handouts
Navigable Slide Index
- Introduction
- Haplotype tagging SNPs
- The htSNP approach
- Tag SNPs in LD blocks (1)
- Tag SNPs in LD blocks (2)
- Tag SNPs in LD blocks (3)
- A simple model
- Indirect association
- Scoring htSNP genotypes
- R2: our recent experience
- Some lessons
- Case-control studies
- Power
- Complexity vs. accuracy
- An experimental study
- Power in CTLA4
- Power in RANK
- Power in TH 5' region 2
- Power in TH-INS-IGF2
- Tests based on locus scoring
- A "multilocus TDT"
- From htSNPs to causal variants
- Selecting htSNPs N=96 (1)
- Selecting htSNPs N=96 (2)
- Selecting htSNPs N=48 (1)
- Selecting htSNPs N=48 (2)
- Selecting htSNPs N=32 (1)
- Selecting htSNPs N=32 (2)
- Selecting htSNPs N=16 (1)
- Selecting htSNPs N=16 (2)
- Quantitative traits
- One df for dominance
- Acknowledgements and reference
Topics Covered
- The htSNP approach
- R-square criterion for assessment
- Power
- Complexity vs. accuracy
- Case studies: 4 gene regions
- From htSNPs to causal variants
- Quantitative traits
- 1 df for dominance
Talk Citation
Clayton, D. (2004, September 1). Searching for genetic association using (haplotype) tagging SNPs [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 13, 2024, from https://doi.org/10.69645/ODPW5613.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. David Clayton has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.