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Topics Covered
- The challenge of developing influenza vaccines
- What is a universal influenza vaccine and how feasible is it?
- Current achievements and problems in the development of a universal influenza vaccine
- The problem of predicting efficacy of universal vaccines and the limits of model animals
Biography
Peter Palese is Chair and Professor of Microbiology, and Professor of Medicine at the Mount Sinai School of Medicine in New York. His research has focused on studying negative-strand RNA viruses with emphasis on influenza viruses. His laboratory developed the first reverse genetics system for negative-strand RNA viruses. He is a member of the National Academy of Sciences.
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Talk Citation
Palese, P. (2018, April 1). Towards developing a universal influenza vaccine [Audio file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2024, from https://doi.org/10.69645/PMWV3993.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Peter Palese, Royalty, Receipt of Intellectual Property Rights/Patent Holder: Merck, S & D, GSK, Medi-immune, Avimed
A selection of talks on Pharmaceutical Sciences
Transcript
Please wait while the transcript is being prepared...
0:00
Interviewer: Professor Palese, thank you for sparing the time today.
I very much enjoyed your talk in the collection on influenza.
The subject today is Universal Influenza Vaccines.
As I understand it,
as one of your research projects,
you are committed to attempting to develop a universal influenza vaccine. Is that right?
Prof. Palese: Correct. Absolutely. So, my name is Peter Palese.
I'm Professor and Chair of Microbiology at the Icahn School of Medicine at Mount Sinai,
this is in Manhattan, New York,
and we are working on the development of new and improved influenza virus vaccines.
As you are probably aware of,
influenza virus vaccines have to be administered every year,
and the reason is that the virus,
the influenza viruses, change,
and every year we have to deal with new slightly different variants,
and therefore, we have to administer influenza virus vaccines on an annual basis.
To avoid that and to make vaccines which would last 20 years or a lifetime,
we and others are trying to develop universal influenza virus vaccines.
Interviewer: You're seeking to do this in humans.
Is there any merit in expanding the concept to
animal hosts from which recombinant viruses may emanate?
Prof. Palese: Okay. So this was a very or is a very complex question you are asking.