Hello I'm Megan Shaw.
I'm from the Icahn School of medicine at Mount Sinai in New York.
I'm going to be talking to you today about
antiviral drugs, and specifically non-HIV antiviral drugs.
So why do we need antiviral drugs?
Antiviral drugs can stop the infection, after it has started i.e.,
they can be used therapeutically;
unlike vaccines which you use prophylactically.
Also drugs are important for viral diseases where preventable vaccines are unavailable.
Another reason is that drugs are important for
viral diseases, where vaccines may not always afford protection.
An example of this is the influenza virus,
which the vaccine has to be changed every year, and sometimes there's a mismatch; or
a new virus may emerge and there's not enough time to make
the vaccine; and therefore antiviral drugs become very important.
Finally drugs can be used as prophylaxis to prevent disease spread to close contact.
On this graph, there are illustrated
the drugs that have been approved for viral diseases until, the present day.
So right now we have
approximately 90 drugs approved to treat nine viral diseases in humans.
Some of these drugs I should note,
include antibodies and immunoglobulin therapy -
which I'm not going to cover in the lecture today.
But you will note that these drugs are dominated by HIV drugs.
So these take up the majority of the approved drugs that we have today.
We have had a number of drugs approved recently for HCV,
and this has dramatically changed the treatment of HCV patients.
I will be covering this in detail today.