Thank you very much for listening to this talk about "Severe Asthma in Children".
I'm Professor Andrew Bush.
I'm a Professor of Pediatrics at Imperial College and
a consultant pediatric chest physician at the Royal Brompton Hospital,
and I'm presenting on behalf of our multidisciplinary team.
I have no conflict of interest with regard to this presentation.
The aims of my presentation are as follows.
I'm going to present three cases of children
representative of the sort of airway diseases referred to us.
The details have been slightly altered to preserve anonymity.
I aim to update our thinking about severe asthma from where
we were in 2008 in light of the National Review of Asthma Deaths.
I'm going to review some novel mechanistic data that we've
discovered in those with true severe therapy-resistant asthma.
And I'm going to propose three very different phenotypes of
'steroid resistant asthma' and discuss their management.