Share these talks and lectures with your colleagues
Invite colleaguesWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at support@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support support@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support support@hstalks.com
We hope you have enjoyed this limited-length demo talk
This is a limited length demo talk; you may
login
or review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Progress of genomics in the past decade
- Complex traits and common diseases
- Host genetics in infectious diseases (publications)
- Pathogen genetics of infectious diseases
- Public health in the age of genomics
- Disruptive potential of infectious diseases
- SARS: cumulative number of reported cases
- Surveillance and control of infectious diseases
- Without genomic surveillance (example)
- With genomic surveillance (example)
- Concept of genomic surveillance
- Host genetics in infectious diseases
- Brief recap of GWAS in NCDs and complex traits
- GWAS hypothesis
- Association studies: genomic variation
- Sampling & ascertainment
- Association studies: quantitative traits
- ANOVA-based analysis
- Indirect associations
- Commercial genotyping chips
- Chips summarizing the human genome
- HapMap SNPs vs. New SNPs
- 1000 Genomes project
- Burden of infectious diseases
- Summary of lesson 1
- Confounding effects of population structure
- Detecting & correcting for population structure
- Principal components analysis
- Admixed populations
- Admixed populations: Thailand
- Evolution of GWAS
- Diverse populations: design issue
- Meta-analysis across different platforms
- Harmonizing SNP content
- Signals of malaria association in The Gambia
- Diverse populations: genetic diversity issue
- Inter-population LD variation
- Inter-population LD variation (examples)
- Conclusions for lesson 2
- Diverse populations: biological issue
- Out of Africa population migration
- Factors driving genetic dissimilarities
- Heterogeneity in infectious diseases
- Additional complexity in infectious diseases
- Confluence of positive selection & host genetics
- Theory of positive selection
- Genomic signatures of positive natural selection
- Fixed & moderately recent mutations
- Established methods to detect positive selection
- iHS & XP-EHH
- Sickle-cell locus in Africans
- Natural selection in Bangladeshi population
- Genetic association in African Americans
- Positive selection & antimalarial resistance
- Summary
Topics Covered
- Statistical genetics of infectious diseases
- Opportunities & challenges of identifying host genetic factors for infectious diseases
- Convergence in evidence between positive selection & host genetic protection to infection
- Population genetics of communities facing greater burden of infectious diseases
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Teo, Y.Y. (2017, April 30). Statistical genetics of infectious diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 27, 2018, from https://hstalks.com/bs/3495/.Talk Information
Statistical genetics of infectious diseases
Published on April 30, 2017
62 min
Other Talks in the Series: Statistical Genetics
Transcript
0:00
Good day, everyone.
My name is YY Teo.
I'm currently
at the National University of Singapore.
And I'm the center director
for the Center for Infectious Diseases
Epidemiology Research.
Today, we're going to talk about
"Statistical Genetics of Infectious Diseases".
0:18
Now, there has been quite a lot of progress
in genomics over the past 15 years.
So in 2001, we started with the sequencing
of the first draft of the human genome.
And we did a spectrum
of about 10 years or decade.
We have now moved from
just sequencing one human,
to sequencing thousands of humans
and also not just the humans,
but also the organisms, the pathogens
that are inside and on the surface
of the skins of humans.
Now given this rapid progress,
there has been a lot of opportunities
and challenges
for the use of genomics
to look at a spectrum of diseases.
0:55
So, if we look at the developments
that have happened
from the period of 2005 to 2015,
in these 10 years,
we have moved from a case
where we knew very little
about the genetics or complex traits
and common diseases, to knowing
in excess of 4,000 specific positions
in the human genome
that have been found to be associated
with the severity of a condition
or with the onset of a particular condition.