Navigable Slide Index

1. Introduction
2. Progress of genomics in the past decade
3. Complex traits and common diseases
4. Host genetics in infectious diseases (publications)
5. Pathogen genetics of infectious diseases
6. Public health in the age of genomics
7. Disruptive potential of infectious diseases
8. SARS: cumulative number of reported cases
9. Surveillance and control of infectious diseases
10. Without genomic surveillance (example)
11. With genomic surveillance (example)
12. Concept of genomic surveillance
13. Host genetics in infectious diseases
14. Brief recap of GWAS in NCDs and complex traits
15. GWAS hypothesis
16. Association studies: genomic variation
17. Sampling & ascertainment
18. Association studies: quantitative traits
19. ANOVA-based analysis
20. Indirect associations
21. Commercial genotyping chips
22. Chips summarizing the human genome
23. HapMap SNPs vs. New SNPs
24. 1000 Genomes project
25. Burden of infectious diseases
26. Summary of lesson 1
27. Confounding effects of population structure
28. Detecting & correcting for population structure
29. Principal components analysis
30. Admixed populations
31. Admixed populations: Thailand
32. Evolution of GWAS
33. Diverse populations: design issue
34. Meta-analysis across different platforms
35. Harmonizing SNP content
36. Signals of malaria association in The Gambia
37. Diverse populations: genetic diversity issue
38. Inter-population LD variation
39. Inter-population LD variation (examples)
40. Conclusions for lesson 2
41. Diverse populations: biological issue
42. Out of Africa population migration
43. Factors driving genetic dissimilarities
44. Heterogeneity in infectious diseases
45. Additional complexity in infectious diseases
46. Confluence of positive selection & host genetics
47. Theory of positive selection
48. Genomic signatures of positive natural selection
49. Fixed & moderately recent mutations
50. Established methods to detect positive selection
51. iHS & XP-EHH
52. Sickle-cell locus in Africans
53. Natural selection in Bangladeshi population
54. Genetic association in African Americans
55. Positive selection & antimalarial resistance
56. Summary

Topics Covered

• Statistical genetics of infectious diseases
• Opportunities & challenges of identifying host genetic factors for infectious diseases
• Convergence in evidence between positive selection & host genetic protection to infection
• Population genetics of communities facing greater burden of infectious diseases

Links

Series:

• Statistical Genetics

Categories:

• Methods
• Microbiology

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Teo, Y.Y. (2017), "Statistical genetics of infectious diseases", in The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (online at https://hstalks.com/bs/3495/)

Talk Information

• Published on April 30, 2017