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Printable Handouts
Navigable Slide Index
- Introduction
- Lecture outline
- Molecular chaperone
- Discovery of GroE and DnaK chaperone machines
- DnaK-DnaJ-GrpE chaperone machinery
- Early studies on DnaK machinery in the 1980s
- The chaperone machinery of DnaK
- The DnaK chaperone cycle in protein folding
- Molecular chaperones as heat-inducible proteins
- Molecular chaperones in bacteria
- Bacterial chaperones as virulence factors
- Salmonella induces heat shock proteins
- Salmonella spp.
- Salmonella is an interesting model organism
- Natural history of Salmonella infection
- Salmonella pathogenicity island (SPI)
- Salmonella type 3 secretion system (T3SS)
- DnaK is essential for survival in macrophages
- DnaK is required for Salmonella invasion
- Salmonella pathogenicity island 1 (SPI1) genes
- Salmonella DnaK-depleted cell
- Genes involved in flagellar biogenesis
- Structure of Clp/Hsp100 chaperones
- Model of substrate degradation by ClpXP protease
- ClpX and systemic Salmonella infection
- ClpX mutant-infected mice
- ClpX-depleted cell shows hyper flagellation
- ClpX and the expression of flagellar regulon
- Flagellar biogenesis in the infectious process
- Salmonella type 3 secretion systems
- Roles of DnaK and Clp in pathogenesis
- GroEL molecule secreted extracellularly
- Helicobacter pylori
- GroEL molecule involves in adherence of H. pylori
- The role of GroEL in adherence to host cells
- Concluding remarks
Topics Covered
- Discovery of major molecular chaperones through the studies on bacteriophage lambda
- Discovery of function of DnaK machinery assisting assembly/disassembly of macromolecule protein structure
- Roles of DnaK chaperone machinery and ClpX chaperone in Salmonella pathogenesis and flagellar biogenesis
- Role of GroEL on bacterial cell surface
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Talk Citation
Yamamoto, T. (2018, April 30). The roles of molecular chaperones in bacterial infection [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 11, 2019, from https://hstalks.com/bs/346/.Publication History
Financial Disclosures
- Prof. Tomoko Yamamoto has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The roles of molecular chaperones in bacterial infection
Other Talks in the Category: Biochemistry
Transcript
0:00
Hi, my name is Tomoko Yamamoto.
I'm Professor of Medical Mycology,
Research Center at Chiba university,
and Asia International Institute of Infectious Disease Control at Teikyo University.
The title of my seminar is the roles of Molecular Chaperones in bacterial Infection.
0:23
I will just outline my seminar here.
First, I overview early studies on bacterial molecular chaperones.
Those are discovery of
major molecular chaperones through their studies on bacteriophage lambda in the 1970s,
and our early study on DnaK chaperone in the 1980s.
It's a discovery of function of DnaK machinery
assisting the assembly and the disassembly of macromolecular structure.
Then, I'll move the subject of this seminar,
roles of molecular chaperones in bacterial infection.
I will describe the roles of DnaK chaperone machinery and
ClpX chaperone on Salmonella pathogenesis and the flagellar biogenesis,
and I will mention roles of GroEL on bacterial cell surface in infection.