Hi, my name is Tomoko Yamamoto.
I'm Professor of Medical Mycology,
Research Center at Chiba university,
and Asia International Institute of Infectious Disease Control at Teikyo University.
The title of my seminar is the roles of Molecular Chaperones in bacterial Infection.
I will just outline my seminar here.
First, I overview early studies on bacterial molecular chaperones.
Those are discovery of
major molecular chaperones through their studies on bacteriophage lambda in the 1970s,
and our early study on DnaK chaperone in the 1980s.
It's a discovery of function of DnaK machinery
assisting the assembly and the disassembly of macromolecular structure.
Then, I'll move the subject of this seminar,
roles of molecular chaperones in bacterial infection.
I will describe the roles of DnaK chaperone machinery and
ClpX chaperone on Salmonella pathogenesis and the flagellar biogenesis,
and I will mention roles of GroEL on bacterial cell surface in infection.
Molecular chaperone was initially defined by Ellis in 1987.
Molecular chaperone is a large and diverse group of proteins that share the properties as
follows: Acts on unfolded and the misfolded polypeptides and assists folding,
helps refolding, and prevents aggregation.
Assist assembly and disassembly of other macromolecular structures,
but which is not permanent component of
these structures when they are performing their normal biological function.