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What’s new for IgA nephropathy part 1: epidemiology and pathogenesis

Part 1 of 2
Published on August 31, 2016   23 min

Other Talks in the Series: The Kidney in Health and Disease

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0:00
Hi, I'm Professor Salvadori from the University of Florence. In this first part of my talks on IgA nephropathy, I will brief you about its epidemiology and physiopathology.
0:19
Let me show you the agenda of the day. And let me start with the definition and the main characteristics of this disease.
0:35
IgA nephropathy represents the most frequent glomerulonephritis. The typical histological sign is a proliferation of glomerular mesangial cells with different aspects on light microscopy, that we'll see later. The hallmark is the deposition of IgA and complement mainly in the mesangial area. And finally, the disease is characterized by extremely different clinical signs.
1:15
Here, you may have a look of the different aspects on light microscopy. Accordingly, you'll understand easily that light microscopy is not useful for a right diagnosis.
1:33
Here you see, on the right-hand side of the slide, the hallmark of the disease that is the deposition of IgA as may be observed looking at immunofluorescence.
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What’s new for IgA nephropathy part 1: epidemiology and pathogenesis

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