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1. Introduction
2. Protein self assembly and protein aggregation
3. Origins of the molecular chaperone concept (1)
4. Rubisco: the world's most abundant protein
5. Rubisco characteristics
6. Rubisco large subunit binding protein
7. Discovery of the chaperonins
8. Homologues of BiP form the hsp70 family
9. Origins of the molecular chaperone concept (2)
10. The march of molecular chaperones
11. Definition of molecular chaperones
12. The molecular chaperone function
13. Protein folding in vivo vs. refolding in vitro
14. The principles of protein self assembly
15. The distinction between folding and assembly
16. Assembly chaperones
17. Why are chaperones required in the nucleus?
18. Effect of nuclear chaperones on nucleosomes
19. Structure and assembly of nucleosomes
20. Functions and structure of nucleoplasmin
21. Model for chaperone function of nucleoplasmin
22. Model for chaperone function of GroEL/GroES
23. Effect of RbcX on Rubisco in Synechococcus
24. RbcX function in cyanobacterial assembly
25. Structure of Rubisco L subunit-RbcX complex

Topics Covered

• Definition of protein self-assembly and aggregation
• First use of the term 'molecular chaperone'
• Nucleoplasmin
• Chloroplast rubisco aggregation
• The chaperonins
• The general chaperone concept
• Definition of 'molecular chaperone'
• The chaperone function
• Protein folding on polysomes
• Macromolecular crowding
• Folding and assembly chaperones
• Nuclear chaperones
• Nucleosome assembly
• Mechanism of nucleoplasmin action
• The rubisco assembly chaperone RbcX

Links

Series:

• Molecular Chaperones

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Ellis, R.J. (2007, October 1). History of the molecular chaperone concept: roles in assembly processes [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/YKNF9012.
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Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Emeritus R. John Ellis has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.