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Navigable Slide Index

1. Introduction
2. Preface
3. Number of disease determinants by effect
4. Linkage mapping
5. Linkage disequilibrium mapping
6. Haplotype frequencies 2 x 2 table
7. History of LD
8. 2-locus case-control haplotype frequencies
9. The optimal measure of allelic association
10. Transforming time into distance
11. The Malecot model
12. Allelic association in random haplotypes
13. Efficiency relative to rho
14. Extensions of the Malecot model
15. LD maps and positional cloning by pairwise LD
16. Construction of LDU maps (1)
17. Construction of LDU maps (2)
18. LDU map of a segment of the MHC
19. Haplotype blocks and the LDU map
20. LDU maps for chromosome 22
21. Positional cloning by linkage disequilibrium
22. Multiple pairwise method
23. Comparisons to allow hypothesis testing
24. Mean error variance and chi square
25. Results from simulations
26. Blocks and steps in Daly et al. (2001)
27. The Haplotype Map (HapMap) Project
28. Parameters of LD in a genome scan
29. The first population comparison for LD (1961)
30. Ethnic samples
31. Error variance and relative efficiency
32. Estimates with a cosmopolitan map
33. Scaling factors in regional maps
34. Predictive variables to score marker pairs
35. Predictive variables to score marker trios
36. Integrated map
37. What next?
38. Revisiting blocks and steps of Daly et al. (2001)
39. Information in haplotypes relative to diplotypes
40. Relative efficiency of maximum chi-square
41. Characterisation of an asthma candidate
42. CYP2D6
43. CYP2D6: haplotype analysis of the same region
44. References

Topics Covered

• The use of LD for localization of disease genes
• The evolutionary theory behind LD maps
• Comparison of alternative metrics and genetic models
• Effect of SNP selection on power
• Extension to haplotype analysis
• The utility of maps that integrate physical, linkage and LD data

Links

Series:

• Genetic Epidemiology I

Categories:

• Genetics & Epigenetics
• Methods

Talk Citation

Morton, N. and Collins, A. (2004, September 1). Optimal use of linkage disequilibrium, haplotypes, and integrated maps for positional cloning [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 19, 2024, from https://hstalks.com/bs/32/.
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Publication History

• Published on September 1, 2004
• Archived on February 25, 2021

Financial Disclosures

• Prof. Newton Morton has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
• Dr. Andrew Collins has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.