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0:00
Hello and welcome
to this talk
entitled
The Genetics of Glioblastoma
as part
of the Henry Stewart Talks
on the genetics of cancers.
My name is Dr. Hai Yan.
I am the Henry Friedman
Professor of Neuro Oncology
at Duke University
where I reside as a member
of the Department of Pathology
under Preston Robert Tisch
Brain Tumor Center.
0:27
It is my privilege
to discuss this content matter
with you today
that honors the work
of people before me
such as doctors Henry Friedman,
Darell Bigner, Bert Vogelstein
and many other
major contributors
to the field
of brain cancer research.
Naturally, I will also include
some summaries
of some of the work
I have contributed
to this important field.
This work outlines the approach
many scientists take
to making further discoveries
for aid in understanding
and the treatment of what is
a terribly deadly disease.
Let's get started.
1:07
I will break this talk down
into three sections
that go through
and involving depths of detail
into the genetics
of glioblastoma.
While the majority of this talk
will highlight the most updated,
presented work in the field,
I will also spend some time
providing a brief summary
of glioma and the hierarchy
by which we classified them.
I will then explain
to the extent
if possible how and why
the use of genetics
impacts the brain cancer
research and treatment.
This field is a critically
important work
to solving the confused cells,
rogue in their behavior
as tumors
and deadly
in their impact on people.
Lastly, I attempt to capture
just how we use genomic research
by using
some compounding stories
along the way.
The featured is that
of isocitrate dehydrogenase
better referred to as IDH.
A curious insight into
how one genomic finding
can unpack a wealth
of knowledge about
the mischievous inner workings
of cancer cells.
Finally, I'd like
to share with you
the very cutting-edge
of genomic research
by discussing a mutation
we discovered
just two years ago called TERT.
I hope you enjoy
the discussion.
Now let's begin.
