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Navigable Slide Index

1. Introduction
2. Overview
3. Apoptosis
4. Extrinsic and intrinsic apoptosis pathways
5. How cancer cells escape apoptosis
6. Caspase-independent pathways
7. Death by more than thousand cuts
8. Introduction to lisosomes and lysosomal cell death
9. Lysosomes - forgotten ''suicide bags'' (1)
10. The intracellular dynamic trafficking of lysosomes
11. Lysosomes - forgotten ''suicide bags'' (2)
12. LMP: lysosomal membrane permeabilization
13. Signals leading to LMP
14. Effect of microtuble destabilizing agents
15. Effect of DNA damaging
16. Lysosome cell death pathways study problems
17. Detection of LMP: lysosomal pH gradient
18. Blue light induces rapid lysosomal leakage
19. Detection of LMP using green light
20. Detection of LMP: immunostaining
21. Detection of LMP: enzymatic activity measurement
22. Lysosomal changes in cancer
23. Transformation of murine embryonic fribroblasts
24. Lysosomal Transformation-associated changes
25. MEFs sensitivity to cathepsin-dependent cell death
26. Transformation and sensitivity to photooxidation
27. How cancer cells escape lysosomal cell death?
28. Siramesine - a drug that targets lysosomes
29. Siramesine - a sigma-2 receptor ligand
30. Siramesine induces apoptosis-like cell death
31. Transformation sensitizes NIH 3T3 cells to the drug
32. Oral administration of siramesine
33. Siramrsine does not induce classic apoptosis
34. Siramesine disrupts the lysosomal pH gradient
35. Involvement of cystein cathepsins
36. Siramesine induces cathepsin release in vitro
37. Lysosomes as targets for future cancer therapy
38. Thanks
39. Thanks to the apo-lab-Copenhagen

Topics Covered

• Cell death in cancer
• Introduction to the lysosomes and lysosomal cell death
• Lysosomal changes in cancer
• Siramesine, a drug that targets lysosomes and kills cancer cells in vitro and in vivo

Links

Series:

• Apoptosis

Categories:

• Cancer
• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation
• Oncology

Talk Citation

Jaattela, M. (2007, October 1). Lysosomal cell death pathways: new possibilities for cancer therapy [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/IXST8279.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Marja Jaattela has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.