• Evolution of the Apoptotic Pathway
• 52 min
  1. Apoptosis in C. elegans

  • Prof. Michael Hengartner
• 46 min
  2. Regulation of apoptosis: lessons from Drosophila and their implications for human health and disease

  • Prof. Hermann Steller
• The Apoptotic Pathway in Humans
• 29 min
  3. The death receptor signalling pathway

  • Dr. Richard Siegel
• 36 min
  4. Mitochondria and apoptosis

  • Prof. Stephen Tait
• Apoptosis Molecules
• 24 min
  5. The Bcl-2 family

  • Dr. David Huang
• 43 min
  6. Caspases

  • Prof. Yuri Lazebnik
• 37 min
  7. Natural caspase inhibitors

  • Prof. Guy Salvesen
• 44 min
  8. Mechanisms of apoptosis from structural biology

  • Prof. Yigong Shi
• 27 min
  9. TRAIL-induced apoptosis: from analysis of the death-inducing signalling complex (DISC) to clinical applicability

  • Dr. Henning Walczak
• Clearance of Apoptotic Cells
• 28 min
  10. Phagocytosis of apoptotic cells

  • Prof. Peter Henson
• Non-Apoptotic Cell Death Programs
• 34 min
  11. Autophagic cell death

  • Prof. Eric Baehrecke
• Apoptosis and Disease
• 64 min
  12. p53 and apoptosis

  • Prof. Moshe Oren
• 47 min
  13. The p53 family: function and molecular mechanisms

  • Prof. Gerry Melino
• 62 min
  14. Apoptosis in the immune system

  • Prof. Peter Krammer
• 68 min
  15. Apoptosis in the nervous system

  • Prof. Pierluigi Nicotera
• Clinical Application of Apoptosis Research
• 49 min
  16. Endothelial cell apoptosis

  • Prof. Richard Kolesnick
• 31 min
  17. Targeting apoptosis pathways in cancer therapy

  • Dr. Simone Fulda
• Archived Lectures *These may not cover the latest advances in the field
• 42 min
  18. Targeting apoptosis pathways in cancer therapy

  • Dr. Irene Ghobrial
• 20 min
  19. Apoptotic pathways in mammals

  • Prof. Douglas Green
• 46 min
  20. Lysosomal cell death pathways: new possibilities for cancer therapy

  • Prof. Marja Jaattela
• 57 min
  21. Degradation of apoptotic cells

  • Prof. Shigekazu Nagata
• 61 min
  22. Signaling during engulfment: the beginnings of a good meal

  • Prof. Kodi Ravichandran
• 29 min
  23. Apoptotic cell clearance deficiencies

  • Prof. Martin Herrmann
• 46 min
  24. Caspase inhibitors in drug discovery

  • Dr. Tom O'Brien
• 28 min
  25. Mitochondria in apoptosis

  • Prof. Jean-Claude Martinou

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Apoptosis and programmed cell death
3. Programmed cell death during digit formation
4. Features of apoptosis
5. Cells undergoing apoptosis
6. Apoptosis roles
7. Induction of apoptosis by caspases
8. Inactive executioner caspase & active caspase
9. Destroying the DNA
10. Substrate cleavage
11. Activation of caspases
12. Initiator caspase activation
13. Protein-protein interaction domains in caspases
14. Death folds
15. Inhibitor of apoptosis proteins
16. Apoptotic pathways in mammals
17. Death receptors
18. Pathway of Fas and TRAIL-receptors
19. Pathway of TNFR-1
20. FLIP inhibits caspase 8 activation
21. Mitochondrial pathway of apoptosis
22. Cytochrome c release during apoptosis
23. Apoptosome
24. APAF-1, caspase 9 and cytochrom c mutant mice
25. The Bcl-2 family proteins
26. Bcl-2 family proteins have similar structures
27. Bax and Bak oligomerization
28. Activation and repression by Bcl-2 proteins
29. MOMP also promotes apoptosis inhibiting XIAP
30. BID bridges between apoptotic pathways
31. Caspase-independent cell death
32. Cells die in the absence of caspase activation
33. Interdigital web: caspase independent cell death
34. Apoptotic cells are removed from the system
35. Phospholipids "scramble" in plasma membrane
36. Apoptotic pathways in mammals

Topics Covered

• Apoptosis and programmed cell death
• Apoptosis: developmental signals, damage or stress, loss of adhesion and oncogenesis
• Caspases: inactive and active
• Death folds
• Inhibitors of apoptosis proteins
• Death receptor (extrinsic) pathway
• Mitochondrial (intrinsic) pathway
• The Bcl-2 family proteins
• Apoptosome
• Activation, repression and de-repression
• Caspase-independent cell death
• Cells die in the absence of caspase activation

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Douglas Green has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.