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- Evolution of the Apoptotic Pathway
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1. Apoptosis in C. elegans
- Prof. Michael Hengartner
- The Apoptotic Pathway in Humans
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3. The death receptor signalling pathway
- Dr. Richard Siegel
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4. Mitochondria and apoptosis
- Prof. Stephen Tait
- Apoptosis Molecules
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5. The Bcl-2 family
- Dr. David Huang
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6. Caspases
- Prof. Yuri Lazebnik
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7. Natural caspase inhibitors
- Prof. Guy Salvesen
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8. Mechanisms of apoptosis from structural biology
- Prof. Yigong Shi
- Clearance of Apoptotic Cells
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10. Phagocytosis of apoptotic cells
- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
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11. Autophagic cell death
- Prof. Eric Baehrecke
- Apoptosis and Disease
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12. p53 and apoptosis
- Prof. Moshe Oren
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13. The p53 family: function and molecular mechanisms
- Prof. Gerry Melino
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14. Apoptosis in the immune system
- Prof. Peter Krammer
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15. Apoptosis in the nervous system
- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
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16. Endothelial cell apoptosis
- Prof. Richard Kolesnick
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17. Targeting apoptosis pathways in cancer therapy
- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
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18. Targeting apoptosis pathways in cancer therapy
- Dr. Irene Ghobrial
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19. Apoptotic pathways in mammals
- Prof. Douglas Green
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20. Lysosomal cell death pathways: new possibilities for cancer therapy
- Prof. Marja Jaattela
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21. Degradation of apoptotic cells
- Prof. Shigekazu Nagata
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22. Signaling during engulfment: the beginnings of a good meal
- Prof. Kodi Ravichandran
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23. Apoptotic cell clearance deficiencies
- Prof. Martin Herrmann
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24. Caspase inhibitors in drug discovery
- Dr. Tom O'Brien
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25. Mitochondria in apoptosis
- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introduction
- Apoptosis and programmed cell death
- Programmed cell death during digit formation
- Features of apoptosis
- Cells undergoing apoptosis
- Apoptosis roles
- Induction of apoptosis by caspases
- Inactive executioner caspase & active caspase
- Destroying the DNA
- Substrate cleavage
- Activation of caspases
- Initiator caspase activation
- Protein-protein interaction domains in caspases
- Death folds
- Inhibitor of apoptosis proteins
- Apoptotic pathways in mammals
- Death receptors
- Pathway of Fas and TRAIL-receptors
- Pathway of TNFR-1
- FLIP inhibits caspase 8 activation
- Mitochondrial pathway of apoptosis
- Cytochrome c release during apoptosis
- Apoptosome
- APAF-1, caspase 9 and cytochrom c mutant mice
- The Bcl-2 family proteins
- Bcl-2 family proteins have similar structures
- Bax and Bak oligomerization
- Activation and repression by Bcl-2 proteins
- MOMP also promotes apoptosis inhibiting XIAP
- BID bridges between apoptotic pathways
- Caspase-independent cell death
- Cells die in the absence of caspase activation
- Interdigital web: caspase independent cell death
- Apoptotic cells are removed from the system
- Phospholipids "scramble" in plasma membrane
- Apoptotic pathways in mammals
Topics Covered
- Apoptosis and programmed cell death
- Apoptosis: developmental signals, damage or stress, loss of adhesion and oncogenesis
- Caspases: inactive and active
- Death folds
- Inhibitors of apoptosis proteins
- Death receptor (extrinsic) pathway
- Mitochondrial (intrinsic) pathway
- The Bcl-2 family proteins
- Apoptosome
- Activation, repression and de-repression
- Caspase-independent cell death
- Cells die in the absence of caspase activation
Talk Citation
Green, D. (2007, October 1). Apoptotic pathways in mammals [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/278/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Douglas Green has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.