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1. Introduction
2. Apoptosis and programmed cell death
3. Programmed cell death during digit formation
4. Features of apoptosis
5. Cells undergoing apoptosis
6. Apoptosis roles
7. Induction of apoptosis by caspases
8. Inactive executioner caspase & active caspase
9. Destroying the DNA
10. Substrate cleavage
11. Activation of caspases
12. Initiator caspase activation
13. Protein-protein interaction domains in caspases
14. Death folds
15. Inhibitor of apoptosis proteins
16. Apoptotic pathways in mammals
17. Death receptors
18. Pathway of Fas and TRAIL-receptors
19. Pathway of TNFR-1
20. FLIP inhibits caspase 8 activation
21. Mitochondrial pathway of apoptosis
22. Cytochrome c release during apoptosis
23. Apoptosome
24. APAF-1, caspase 9 and cytochrom c mutant mice
25. The Bcl-2 family proteins
26. Bcl-2 family proteins have similar structures
27. Bax and Bak oligomerization
28. Activation and repression by Bcl-2 proteins
29. MOMP also promotes apoptosis inhibiting XIAP
30. BID bridges between apoptotic pathways
31. Caspase-independent cell death
32. Cells die in the absence of caspase activation
33. Interdigital web: caspase independent cell death
34. Apoptotic cells are removed from the system
35. Phospholipids "scramble" in plasma membrane
36. Apoptotic pathways in mammals

Topics Covered

• Apoptosis and programmed cell death
• Apoptosis: developmental signals, damage or stress, loss of adhesion and oncogenesis
• Caspases: inactive and active
• Death folds
• Inhibitors of apoptosis proteins
• Death receptor (extrinsic) pathway
• Mitochondrial (intrinsic) pathway
• The Bcl-2 family proteins
• Apoptosome
• Activation, repression and de-repression
• Caspase-independent cell death
• Cells die in the absence of caspase activation

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 13, 2020

Financial Disclosures

• Prof. Douglas Green has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.