Genomic insights into gene regulation by cohesin

Published on February 4, 2014   60 min

Other Talks in the Series: Epigenetics, Chromatin, Transcription and Cancer

0:00
My name is Dale Dorsett from the Department of Biochemistry and Molecular Biology at the Saint Louis University School of Medicine, and I'm going to talk about gene regulation by cohesin in Drosophila, which has provided insights into certain human conditions.
0:18
In my talk, I'm going to cover four major points. The first is, is that sister chromatids cohesion proteins regulate many genes that are important for growth and development? The second point is going to be about a specific mechanism by which cohesin controls gene expression, and that said, cohesin collaborates with Polycomb silencing proteins to restrain, but not actually silence genes. We're also going to talk about how cohesin binds genes that have paused RNA polymerase, and how it controls the ability of that paused polymerase to become elongating polymerase. And finally, I'm going to summarize how gene regulation by cohesin can explain diverse developmental deficits that occur in a human genetic syndrome, Cornelia de Lange syndrome.
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Genomic insights into gene regulation by cohesin

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