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1. Introduction
2. Short range interaction with surrounding cells
3. DSS induces injury in mammals, lethality in flies
4. DSS feeding increases enteroblast number
5. Tissue injury caused by DSS
6. Hippo/Yorki tumor suppressor pathway (1)
7. Hippo/Yorki tumor suppressor pathway (2)
8. Hippo/Yorki pathway mediates ISC proliferation
9. Bleomycin as a tissue damaging agent
10. Bleomycin damaging mechanism
11. Enterocytes damage can stimulate ISC division
12. Enterocytes regulate ISC proliferation
13. Long range interactions
14. Insulin receptor activation to midgut proliferation
15. Activated insulin receptor expression
16. InR pathway mutants suppress stem cell division
17. Systemic and local insulin regulate ISC division
18. ISC regulation and tissue repair - summary
19. Acknowledgments

Topics Covered

• The adult Drosophila midgut contains tissue specific intestinal stem cells (ISCs)
• ISCs are the only dividing cells in the midgut and are responsible for maintaining midgut homeostasis and regeneration
• The ISC division gives rise to a renewed stem cell and an enteroblast, which can differentiate into secretory enteroendocrine cells or absorptive enterocytes
• Intrinsic factors such as Tuberous Sclerosis Complex and Myc coordinate the growth and division of ISCs
• Extrinsic factors such as Epidermal Growth Factor from surrounding cells and the interaction with basement membrane also regulate the rate of ISC division
• Insulin secreted from CNS function as a long-range growth factor to control ISC activity and therefore intestinal tissue homeostasis

Links

Series:

• The Legacy of Drosophila Genetics

Categories:

• Cell Biology

Therapeutic Areas:

• Gastroenterology & Nephrology

Talk Citation

Publication History

• Published on January 5, 2014
• Reviewed on September 25, 2017

Financial Disclosures

• Prof. Tony Ip has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.