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Intestinal stem cell-mediated repair in Drosophila 1

Part 1 of 2
Published on January 5, 2014 Reviewed on September 25, 2017   34 min

A selection of talks on Gastroenterology & Nephrology

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0:00
Hi, this is Tony Ip, professor of molecular medicine at the University of Massachusetts Medical School. In this talk I will discuss with you about intestinal stem cell-mediated repair in drosophila. The human gastrointestinal tract—
0:19
or GI tract—is a very complex organ. It's often referred to as "organs within organ." Each of those individual organs have their own stem cells to mediate tissue homeostasis and repair. The human GI tract is particularly suitable to study tissue regeneration because many, many cells are shed everyday, and the stem cells are required to go through many divisions to repair and replenish all the lost cells. The right-hand side of the slide is the GI tract of the model organism, Drosophila melanogaster, the common fruit fly. The size of the GI tract of common fruit flies is only 2 cm long. So it's a simple organism that can be used to study many aspects of GI biology. This is the life cycle of drosophila.
1:20
The whole takes about 7 to 14 days to complete. The adults mate and lay embryos. The embryo takes about 24 hours to hatch as 1st instar larvae. The larvae will molt 2 times to become 3rd instar larvae and then turn into pupae to go through metamorphosis and hatch after about 7 days to become adult flies again. One reason we use drosophila as a model

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