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Biomedical Basics

Chronic inflammation mechanisms

  • Created by Henry Stewart Talks
Published on September 30, 2026   4 min

A selection of talks on Immunology & Inflammation

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This session centers on chronic inflammation mechanisms, offering a structured look at how chronic inflammation is sustained by persistent immune responses and regulatory failures. We will examine the cellular and molecular mechanisms involved, including the roles of key cytokines and immune cell types. The wide ranging impact of chronic inflammation on diseases such as obesity, diabetes, cardiovascular disease, and autoimmune disorders will be discussed. Finally, we will explore how treatment approaches target immune pathways to restore balance and resolve chronic inflammation. Chronic inflammation is a persistent maladaptive immune response, distinct from the self limiting nature of acute inflammation that protects us from infection or injury. Chronic inflammation is sustained by ongoing exposure to an offending agent or a failure in regulatory mechanisms to resolve the immune response. Instead of providing defense, it undermines tissue integrity. Immune dysregulation drives persistent cell activation, excessive cytokine release, and tissue damage, fueling many metabolic and auto immune diseases. Chronic inflammation is marked by persistent pro inflammatory cytokines, chemokines, and altered immune cell balance in tissue. Key cytokines like TNF Alpha, L one Beta, IL six, IL 17, and interferon gamma drive recruitment and activation of macrophages, dendritic cells, and lymphocytes. Chronic lesions are dominated by

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