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1. Introduction
2. Classification of hepatic encephalopathy
3. Hepatic encephalopathy in cirrhosis (1)
4. Hepatic encephalopathy in cirrhosis (2)
5. Transjugular intrahepatic portosystemic shunt
6. Hepatic encephalopathy post-TIPS
7. Survival in TIPS patients as a function of HE grade
8. Neuropathology of HE in chronic liver failure
9. Pathogenesis of HE in cirrhosis: neuroimaging (1)
10. T1-weighted MRI due to manganese deposition
11. Cirrhosis-related Parkinsonism: MRI findings
12. Cirrhosis-related Parkinsonism
13. Pathogenesis of HE in cirrhosis: neuroimaging (2)
14. PET studies in cirrhosis (1)
15. Deactivation of anterior cingulate cortex
16. NCT-B test
17. PET studies in cirrhosis (2)
18. 13NH3 PET images of brain in a cirrhotic patient
19. Neuroinflammation and HE in cirrhosis
20. SIRS in cirrhosis
21. Circulating TNF alpha in cirrhotic patients
22. Serum TNF alpha in HE grade improvement
23. Microglial activation in biliary cirrhosis model
24. Translocator protein and HE in cirrhosis
25. Translocator protein
26. Translocator protein complex
27. IBP - a key subunit of translocator protein
28. Increased translocator protein sites in HE brain
29. PET imaging using the translocator protein ligand
30. Translocator protein activation
31. Modulatory site for neurosteroids
32. GABA-A receptor activation by neurosteroids
33. Allopregnanolone levels and hepatic coma
34. Prevention and treatment of HE in cirrhosis (1)
35. Treatment of precipitating factors
36. Nutrition
37. Non-metabolizeable disaccharides
38. Antibiotics
39. L-ornithine L-aspartate lowers ammonia levels
40. Summary
41. Prevention and treatment of HE in cirrhosis (2)
42. Flumazenil in HE: results of a meta-analysis
43. Emerging new therapeutic approaches
44. Take home messages (1)
45. Take home messages (2)
46. Acknowledgements

Topics Covered

• Classification of hepatic encephalopathy
• Hepatic encephalopathy in cirrhosis
• Transjugular intrahepatic portosystemic shunt (TIPS)
• Hepatic encephalopathy post-TIPS
• Neuropathology of hepatic encephalopathy in chronic liver failure
• Cirrhosis-related Parkinsonism
• PET studies in cirrhosis
• Neuroinflammation and hepatic encephalopathy in cirrhosis
• Systemic inflammatory response syndrome (SIRS) in cirrhosis
• Translocator protein and hepatic encephalopathy in cirrhosis
• Modulatory site for neurosteroids
• Prevention and treatment of hepatic encephalopathy in cirrhosis
• Emerging new therapeutic approaches

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Butterworth, R.F. (2013, November 5). Hepatic encephalopathy in cirrhosis: a disorder of glial-neuronal signalling [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/ITJG4890.
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Publication History

• Published on November 5, 2013

Financial Disclosures

• Prof. Roger F. Butterworth, Speaker’s Bureau: Merz Pharmaceuticals, Frankfurt, Germany.